Alpha Lipoic Acid
Alpha-lipoic acid (ALA) is a sulfur-containing compound that functions as a cofactor in mitochondrial energy production. It is synthesized in small amounts by the body and found naturally in organ meats, spinach, and broccoli. ALA is unique among antioxidants because it is both water- and fat-soluble, allowing it to operate across diverse cellular environments.
Research Evidence
Provides systemic antioxidant protection
ModerateBenefits cognitive function in healthy adults
LimitedReduces symptoms of diabetic peripheral neuropathy
StrongRegenerates other endogenous antioxidants
ModerateImproves insulin sensitivity in type 2 diabetes
ModerateExpert Evidence
31 references from 2 experts
2024
2023
2021
Safety & Cautions
Side Effects
- Nausea
- Skin rash
- Potential blood sugar drops when combined with diabetes medication
- Stomach discomfort
ALA is generally well-tolerated at standard doses. People taking blood sugar-lowering medications should monitor glucose closely, as ALA may enhance their effects.
Pairs Well With
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