Curcumin

Varies

Curcumin is the principal polyphenol found in turmeric root (Curcuma longa), responsible for its characteristic yellow color. It has been widely studied for anti-inflammatory and antioxidant effects, though its naturally poor bioavailability means absorption-enhanced formulations are typically required for meaningful blood levels.

Andrew HubermanStopped

Rhonda PatrickReported use

Research Evidence

May improve symptoms of depression as an adjunct therapy

Moderate

Reduces markers of systemic inflammation

Strong

May support cardiovascular health markers

Limited

Supports exercise recovery and reduces muscle soreness

Moderate

Improves pain and function in knee osteoarthritis

Strong

Source: Examine.com

Expert Evidence

45 references from 4 experts

“I do take things like turmeric, curcumin, you know these polyphenols of which are xenobiotics and I'm interested in like can I take my curcumin at a certain time of day and it's more effective.”

Dr. Satchin Panda on Practical Implementation of Time-Restricted Eating & Shift Work Strategies

1:43:12

3 references in 3 episodes from 2017–2023

Safety & Cautions

Side Effects

Mild gastrointestinal discomfort
Nausea at high doses
Rare but serious liver injury
Potential interaction with blood-thinning medications

While generally well-tolerated at standard doses, rare cases of serious liver injury have been reported with curcumin supplements — consult a healthcare provider before use, especially if you have existing liver conditions or take medications metabolized by the liver.

Pairs Well With

Omega-3 Fatty Acids (EPA)Vitamin D3

Price Comparison

From $0.07/ct

C

CarlyleBest Value

4.7

•180 ct

$0.07/ct

$12.49 total

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