Omega-3 Fatty Acids (EPA)

Omega-3 fatty acids, primarily EPA (eicosapentaenoic acid) and DHA (docosahexaenoic acid), are essential polyunsaturated fats found abundantly in fatty fish like salmon, mackerel, and sardines, as well as in algae-based supplements. They are among the most extensively researched dietary supplements, with decades of evidence supporting roles in cardiovascular health, brain function, and systemic inflammation reduction.

Gil CarvalhoReported use

Andy GalpinReported use

Andrew HubermanReported use

Rhonda PatrickReported use

Stacy SimsReported use

Brad StanfieldReported use

Research Evidence

May improve symptoms of depression, particularly with higher EPA ratios

Moderate

May support metabolic rate when taken at higher doses

Limited

Reduces blood triglyceride levels

Strong

Supports cardiovascular health and reduces heart disease risk

Strong

Supports cognitive function and brain health maintenance

Moderate

Reduces systemic inflammation markers

Strong

Source: Examine.com

Expert Evidence

293 references from 6 experts

“With breakfast, I take about one gram of fish oil.”

Rhonda Patrick's EXACT Supplement Routine (doses, timing, & brands revealed)

1:08

101 references in 37 episodes from 2013–2025

Safety & Cautions

Side Effects

Fishy aftertaste or burping
Mild digestive discomfort
Slightly increased bleeding time at high doses
Occasional nausea

Omega-3 supplements are generally well-tolerated at standard doses. Those on blood-thinning medications should consult a physician before taking high doses, as omega-3s may have mild anticoagulant effects.

Pairs Well With

Vitamin D3 Curcumin Magnesium CoQ10

Price Comparison

From $0.07/ct

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NOW FoodsBest Value

4.7

•180 ct

$0.07/ct

$12.84 total

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