DIM
Diindolylmethane (DIM) is a bioactive compound produced when the body digests indole-3-carbinol, found abundantly in cruciferous vegetables such as broccoli, cauliflower, and Brussels sprouts. It has gained attention for its ability to influence estrogen metabolism, shifting the balance toward less potent estrogen metabolites. DIM is widely studied in the context of hormonal health for both men and women.
Expert Evidence
7 references from 1 expert
“I do not recommend DIM.”
Dr. Andy Galpin: How to Assess & Improve All Aspects of Your Fitness | Huberman Lab Guest Series
2:00:537 references in 5 episodes from 2022–2023
Huberman generally recommends against DIM for most people, stating multiple times that he doesn't recommend it, though he acknowledges a potential exception for athletes. There is no evidence of personal use. He notes DIM may help balance estrogen metabolism but cautions about digestive side effects.
Benefits
DIM (diindolylmethane) may help balance estrogen metabolism and support hormonal health.
Best Practices
Take 100-200 mg per day, preferably with meals.
Cautions
Huberman repeatedly states he does not recommend DIM for most people, with a possible exception for athletes. DIM may cause digestive upset or changes in urine color.
Side Effects
- Darkened urine
- Mild gastrointestinal discomfort
- Headache at higher doses
- Changes in menstrual cycle timing