Sulforaphane (Glucoraphanin)
Sulforaphane is an isothiocyanate compound concentrated in cruciferous vegetables, with broccoli sprouts being the richest dietary source. It is one of the most studied phytochemicals in cancer prevention and cellular defense research. Supplemental forms typically provide sulforaphane directly or its precursor glucoraphanin, sometimes paired with the enzyme myrosinase to improve conversion.
Research Evidence
Activates Nrf2-mediated antioxidant and detoxification pathways
StrongIncreases glutathione levels and phase II enzyme activity
StrongSupports improvements in autism spectrum behavioral scores
ModeratePotential neuroprotective effects against cognitive decline
LimitedMay slow progression of certain cancer biomarkers
ModerateReduces biomarkers of inflammation and oxidative stress
StrongExpert Evidence
53 references from 4 experts
“I've really gotten back on the sulforaphane train and I take sulforaphane.”
Rhonda Patrick's Top 5 Supplements
1:3045 references in 14 episodes from 2013–2025
Safety & Cautions
Side Effects
- Mild gastrointestinal discomfort
- Bloating or gas
- Heartburn at higher doses
- Loose stools
Sulforaphane is generally well-tolerated at commonly studied doses, and clinical trials in healthy adults have not shown thyroid disruption or liver toxicity. Those on blood-thinning medications or undergoing cancer treatment should consult a healthcare provider before supplementing.
Pairs Well With
Price Comparison
From $0.16/ct
N
NutricostBest Value
4.6
•120 ct$0.16/ct
$18.95 total
S
Swanson Vision Defense
4.4
•60 ct$0.74/ct
$44.29 total
A
Avmacol
4.6
•60 ct$1.10/ct
$65.99 total
T
Thorne Crucera-SGS (Broccoli Seed Extract)
4.7
•60 ct$1.12/ct
$67.00 total