Back to all supplements

    Berberine

    Berberine is a yellow alkaloid naturally present in several plants, including goldenseal, Oregon grape, and barberry. It has a long history in traditional Chinese and Ayurvedic medicine and has gained significant attention in modern research for its potent effects on blood sugar regulation and metabolic health.

    Andrew Huberman
    Andrew HubermanTakes it
    Research Evidence
    Activates AMPK pathway to support metabolic function
    Strong
    May support healthy body composition as part of metabolic optimization
    Moderate
    Potential benefits for gut microbiome diversity
    Limited
    Supports healthy blood glucose levels
    Strong
    May improve cholesterol markers including LDL reduction
    Moderate
    Source: Examine.com

    Expert Evidence

    53 references from 4 experts

    “I've tried berberine before. If you take berberine and you have not ingested carbohydrates, many people, including myself, experience a splitting headache.”

    Effects of Fasting & Time Restricted Eating on Fat Loss & Health | Huberman Lab Essentials

    24:39
    Safety & Cautions

    Side Effects

    • Gastrointestinal discomfort (cramping, diarrhea)
    • Nausea, especially at higher doses
    • Potential interactions with medications metabolized by the liver
    • Possible lowering of blood sugar to uncomfortable levels when combined with other glucose-lowering agents
    Berberine is generally well-tolerated at standard doses when taken with food, but its potent glucose-lowering effects mean it should be used cautiously alongside diabetes medications or other blood-sugar-lowering supplements. Consulting a healthcare provider before starting berberine is strongly recommended, particularly for those on prescription medications.
    Pairs Well With
    Alpha-GPCOmega-3 Fatty Acids (EPA)
    Price Comparison
    From $0.33/ct
    N
    NutricostBest Value
    4.5
    •60 ct

    $0.33/ct

    $19.89 total

    Buy
    Report an error