Alpha-GPC
Alpha-GPC (alpha-glycerophosphocholine) is a highly bioavailable choline compound that occurs naturally in the brain and is also found in small amounts in foods like eggs and organ meats. It rapidly converts to phosphatidylcholine after ingestion, making it one of the most efficient ways to deliver choline to the central nervous system. It is widely used for cognitive support and as a sports performance aid.
Research Evidence
May slow cognitive decline in older adults at high doses
ModerateImproves choline status more efficiently than other choline forms
ModerateSupports focus and attention when taken before cognitive tasks
ModerateEnhances acute power output during high-intensity exercise
ModerateIncreases acetylcholine availability in the brain
StrongExpert Evidence
53 references from 2 experts
“And indeed, I use these myself. The most effective one I've found is alpha GPC.”
Tools to Improve Your Focus & Concentration | Huberman Lab Essentials
Oct 1, 202629:2852 references in 29 episodes from 2021–2026
Safety & Cautions
Side Effects
- Headache
- Heartburn or GI discomfort
- Dizziness
- Fishy body odor at high doses
Alpha-GPC is generally well-tolerated at standard doses. Individuals taking cholinergic medications or acetylcholinesterase inhibitors should consult a healthcare provider before supplementing, as effects on acetylcholine levels may compound.
Pairs Well With
Price Comparison
From $0.21/ct
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4.6
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$42.99 total