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    Beta-Carotene

    Varies

    Beta-carotene is a red-orange carotenoid pigment abundant in carrots, sweet potatoes, and leafy greens. It serves as a provitamin A compound, meaning the body converts it to retinol (vitamin A) on an as-needed basis. While dietary beta-carotene from whole foods is associated with health benefits, supplemental forms have raised significant safety concerns in clinical trials.

    Research Evidence
    May increase all-cause mortality when taken as a supplement
    Moderate
    Converts to vitamin A to support vision and immune function
    Strong
    Increases lung cancer risk in smokers when supplemented
    Strong
    Provides photoprotective benefits against UV-induced skin damage
    Limited
    Dietary intake associated with reduced risk of certain cancers
    Moderate

    Expert Evidence

    3 references from 2 experts

    Recommends against

    “The US Preventative Services Task Force concluded with moderate certainty that there are harms from supplementing with beta-carotene, and those harms outweigh the benefits. They also recommend against using vitamin E supplements due to evidence that both may increase mortality.”

    Top 5 Supplements With STRONG Evidence Of Benefit

    11:43
    Brad Stanfield

    2 references in 2 episodes from 2023–2024

    AI-generated summary

    Brad Stanfield recommends against supplementing with beta-carotene, citing the US Preventative Services Task Force's conclusion that harms outweigh benefits and Cochrane review evidence that antioxidant supplements including beta-carotene may increase mortality. No personal use, dosing guidance, or specific benefit claims are present—both references are purely cautionary.

    Recommends against

    “It has been shown that the lungs of smokers are a highly oxidative environment, and in combination with deficiencies in certain antioxidants such as vitamin C and E, carotenoids under these highly oxidative conditions can actually get cleaved into products that damage DNA, which has been shown to cause cancer.”

    Rebuttal to Anti-Vitamin Editorial: "Enough is Enough"

    9:24
    Rhonda Patrick

    1 reference in 1 episode from 2014

    AI-generated summary

    Rhonda Patrick recommends against beta-carotene supplementation for smokers, citing research that the highly oxidative lung environment of smokers can cause carotenoids to cleave into DNA-damaging products that promote cancer, especially when combined with deficiencies in vitamins C and E. No personal use, dosing guidance, or benefits are discussed.

    2024
    2023
    2014
    Safety & Cautions

    Side Effects

    • Carotenodermia (orange skin discoloration)
    • Increased lung cancer risk in smokers
    • Potential increase in all-cause mortality
    • Gastrointestinal discomfort
    The US Preventive Services Task Force recommends against beta-carotene supplementation due to evidence of increased mortality and lung cancer risk, particularly in smokers and those exposed to asbestos. Supplemental beta-carotene should be avoided unless specifically directed by a healthcare provider.
    Pairs Well With
    Price Comparison
    From $0.07/ct
    N
    NOW FoodsBest Value
    5
    180 ct

    $0.07/ct

    $11.99 total

    S
    Solaray
    4.5
    90 ct

    $0.15/ct

    $13.49 total

    S
    Simply Nature's Pledge
    4.5
    90 ct

    $0.67/ct

    $59.95 total