Beta-Carotene
Beta-carotene is a red-orange carotenoid pigment abundant in carrots, sweet potatoes, and leafy greens. It serves as a provitamin A compound, meaning the body converts it to retinol (vitamin A) on an as-needed basis. While dietary beta-carotene from whole foods is associated with health benefits, supplemental forms have raised significant safety concerns in clinical trials.
Expert Evidence
3 references from 2 experts

“The US Preventative Services Task Force concluded with moderate certainty that there are harms from supplementing with beta-carotene, and those harms outweigh the benefits. They also recommend against using vitamin E supplements due to evidence that both may increase mortality.”
Top 5 Supplements With STRONG Evidence Of Benefit
11:432 references in 2 episodes from 2023–2024
Brad Stanfield recommends against supplementing with beta-carotene, citing the US Preventative Services Task Force's conclusion that harms outweigh benefits and Cochrane review evidence that antioxidant supplements including beta-carotene may increase mortality. No personal use, dosing guidance, or specific benefit claims are present—both references are purely cautionary.

“It has been shown that the lungs of smokers are a highly oxidative environment, and in combination with deficiencies in certain antioxidants such as vitamin C and E, carotenoids under these highly oxidative conditions can actually get cleaved into products that damage DNA, which has been shown to cause cancer.”
Rebuttal to Anti-Vitamin Editorial: "Enough is Enough"
9:241 reference in 1 episode from 2014
Rhonda Patrick recommends against beta-carotene supplementation for smokers, citing research that the highly oxidative lung environment of smokers can cause carotenoids to cleave into DNA-damaging products that promote cancer, especially when combined with deficiencies in vitamins C and E. No personal use, dosing guidance, or benefits are discussed.
Side Effects
- Carotenodermia (orange skin discoloration)
- Increased lung cancer risk in smokers
- Potential increase in all-cause mortality
- Gastrointestinal discomfort
$0.07/ct
$11.99 total
$0.15/ct
$13.49 total
$0.67/ct
$59.95 total