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    DHEA

    Morning

    DHEA (dehydroepiandrosterone) is a steroid hormone naturally produced by the adrenal glands that acts as a building block for the body's sex hormones, including testosterone and estrogen. Production peaks in early adulthood and steadily declines with age, dropping by roughly 80% by age 70. It is one of the most abundant circulating steroid hormones in the body.

    Andrew Huberman
    Andrew HubermanStopped
    Research Evidence
    No demonstrated benefit for exercise performance
    Strong
    May improve bone mineral density in older adults
    Moderate
    Increases testosterone levels in women
    Strong
    Does not meaningfully raise testosterone in men
    Strong
    May support mood and reduce depressive symptoms
    Moderate
    May improve skin health and hydration in aging populations
    Limited
    Source: Examine.com

    Expert Evidence

    5 references from 3 experts

    “DHEA will increase both testosterone and estrogen. The extent to which it increases one or the other will depend on whether or not you have a lot of aromatase.”

    The Science of How to Optimize Testosterone & Estrogen

    27:30
    2024
    2021
    Safety & Cautions

    Side Effects

    • Acne or oily skin
    • Hair loss in susceptible individuals
    • Hormonal imbalance at high doses
    • Mood changes or irritability
    Because DHEA is a hormone precursor, it can shift the balance of sex hormones in unpredictable ways, particularly at doses above 50 mg. Individuals with hormone-sensitive conditions should consult a healthcare provider before use, and periodic blood work is recommended to monitor hormone levels.
    Pairs Well With
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