Methylated Folate + B12
Methylated folate (5-MTHF) and methylcobalamin are the bioactive, coenzyme forms of folate and vitamin B12 respectively. Unlike synthetic folic acid or cyanocobalamin, these methylated forms bypass several enzymatic conversion steps, making them particularly valuable for individuals with genetic polymorphisms in the MTHFR gene that impair folate metabolism. Together, they are best known for supporting methylation — a fundamental biochemical process involved in DNA synthesis, neurotransmitter production, and homocysteine clearance.
Expert Evidence
2 references from 1 expert
“My mother-in-law is homozygous for MTHFR, her enzyme only works at about 10 to 20% efficiency. Nothing got her blood pressure into a normal range until we identified she had MTHFR and got her supplementing with 5-methylfolate and methylcobalamin.”
Tim Ferriss on Ketosis, Microbiome, Lyme Disease, and Biomarkers
10:032 references in 2 episodes from 2015
Rhonda Patrick recommends methylated folate (5-MTHF) and methylcobalamin (B12) specifically for individuals with MTHFR gene polymorphisms to lower homocysteine levels, citing both research and a personal family example where supplementation normalized her mother-in-law's blood pressure after other interventions failed. No specific dosing guidance, personal use, or cautions are discussed.
Side Effects
- Overstimulation or anxiety at high doses
- Headache
- Insomnia
- Irritability
- Nausea
$0.09/ct
$8.10 total
$0.10/ct
$11.50 total
$0.14/ct
$12.70 total
$0.30/ct
$29.90 total
$0.35/ct
$42.00 total
$0.37/ct
$21.97 total