Resveratrol
Resveratrol is a polyphenol compound naturally present in red grape skins, berries, peanuts, and Japanese knotweed. It gained widespread attention for its proposed ability to activate sirtuin proteins and mimic caloric restriction, though decades of research and billions in funding have yielded limited convincing evidence of benefit in humans.
Expert Evidence
7 references from 1 expert
“There are no clear benefits from resveratrol supplements. However there are likely harms. In 27 older men who were put on an exercise program, resveratrol supplements blunted the positive effects of exercise when compared to placebo.”
Avoid These Popular Supplements (Damaging Side Effects)
1:597 references in 6 episodes from 2021–2023
Brad Stanfield strongly recommends against resveratrol, citing billions of dollars in research with no robust human evidence of benefit, poor bioavailability, and documented harms including lowered testosterone and blunted exercise benefits. There is no evidence of personal use, no benefits discussed, and no dosing guidance provided.
Cautions
Resveratrol is poorly absorbed and rapidly broken down by the liver, has been shown to lower testosterone levels, blunt the positive effects of exercise, and may increase cholesterol levels. Clinical guidelines from UpToDate explicitly do not recommend it.
Side Effects
- Gastrointestinal discomfort
- Nausea at higher doses
- Possible increase in cholesterol levels
- Potential reduction in testosterone levels
- May interfere with exercise adaptations
$0.09/ct
$16.49 total
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$19.19 total
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$24.00 total
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$29.95 total
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$21.66 total
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$0.77/ct
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$40.00 total
$1.67/ct
$49.95 total