Resveratrol
Varies
Resveratrol is a polyphenol compound naturally present in red grape skins, berries, peanuts, and Japanese knotweed. It gained widespread attention for its proposed ability to activate sirtuin proteins and mimic caloric restriction, though decades of research and billions in funding have yielded limited convincing evidence of benefit in humans.
Research Evidence
Benefits metabolic health in type 2 diabetes
LimitedActivates sirtuin pathways in cell and animal models
ModerateExtends lifespan or slows aging in humans
LimitedImproves cardiovascular risk markers in humans
LimitedProvides antioxidant protection in vitro
ModerateExpert Evidence
57 references from 3 experts
Safety & Cautions
Side Effects
- Gastrointestinal discomfort
- Nausea at higher doses
- Possible increase in cholesterol levels
- Potential reduction in testosterone levels
- May interfere with exercise adaptations
While generally tolerated at moderate doses, resveratrol has shown signals of harm in some studies, including adverse effects on cholesterol and testosterone. It is not recommended by major clinical guidelines, and individuals on blood thinners or hormone-sensitive medications should exercise particular caution.
Pairs Well With
Price Comparison
From $0.08/ct
C
CarlyleBest Value
4.7
•180 ct$0.08/ct
$14.44 total
D
DEAL SUPPLEMENT
4.7
•240 ct$0.10/ct
$24.99 total
A
aSquared Nutrition
4.6
•180 ct$0.17/ct
$29.95 total
L
Luma Nutrition
4.6
•60 ct$0.59/ct
$35.16 total
P
Primal Harvest
4.4
•60 ct$0.77/ct
$46.30 total
M
Momentous
4.7
•30 ct$1.67/ct
$49.99 total