Pterostilbene
Varies
Pterostilbene is a naturally occurring polyphenol found predominantly in blueberries, grapes, and certain tree barks. It is a methylated derivative of resveratrol with significantly improved oral bioavailability due to its two methoxy groups, which enhance lipophilicity and metabolic stability. It has attracted research interest for its antioxidant, anti-inflammatory, and neuroprotective properties.
Research Evidence
Anti-inflammatory activity via NF-kB pathway modulation
LimitedSupport for healthy blood glucose and lipid levels
ModerateImproved bioavailability compared to resveratrol
StrongNeuroprotective effects and cognitive function support
LimitedAntioxidant and free radical scavenging activity
ModerateExpert Evidence
4 references from 1 expert
“These are all phytochemicals that also activate stress response genes.”
How Vitamin D, Omega-3s, & Exercise May Increase Longevity | Dr. Rhonda Patrick
44:104 references in 4 episodes from 2016–2023
2023
2020
2019
2016
Safety & Cautions
Side Effects
- Mild increase in LDL cholesterol at higher doses
- Gastrointestinal discomfort
- Headache
Pterostilbene is generally well-tolerated in human studies at typical supplement doses. However, some research has noted modest LDL cholesterol elevations at higher intakes, so individuals with dyslipidemia should monitor lipid panels when supplementing.
Pairs Well With
Price Comparison
From $0.12/ct
N
NatureBellBest Value
4.5
•200 ct$0.12/ct
$23.95 total
D
Double Wood Supplements
4.5
•60 ct$0.33/ct
$19.95 total
S
Sunergetic
4.6
•60 ct$0.33/ct
$19.95 total
P
ProHealth
4.4
•60 ct$0.49/ct
$29.15 total