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    Pterostilbene

    Varies

    Pterostilbene is a naturally occurring polyphenol found predominantly in blueberries, grapes, and certain tree barks. It is a methylated derivative of resveratrol with significantly improved oral bioavailability due to its two methoxy groups, which enhance lipophilicity and metabolic stability. It has attracted research interest for its antioxidant, anti-inflammatory, and neuroprotective properties.

    Research Evidence
    Anti-inflammatory activity via NF-kB pathway modulation
    Limited
    Support for healthy blood glucose and lipid levels
    Moderate
    Improved bioavailability compared to resveratrol
    Strong
    Neuroprotective effects and cognitive function support
    Limited
    Antioxidant and free radical scavenging activity
    Moderate

    Expert Evidence

    1 reference from 1 expert

    Discusses

    “Blueberries contain pterostilbene which is chemically similar to resveratrol and has been shown to lower triglycerides and blood glucose levels in mice. Pterostilbene has also been shown to be more potent than resveratrol in improving cognitive function.”

    Smoothie #2: Prebiotics, Phytochemicals, "Anti-Nutrients" & Hydrolyzed Collagen

    8:51
    Rhonda Patrick

    1 reference in 1 episode from 2016

    AI-generated summary

    Rhonda Patrick highlights pterostilbene as a compound found in blueberries that is chemically similar to resveratrol but more potent for cognitive function. She cites mouse studies showing it lowers triglycerides and blood glucose. No evidence of personal use, no dosing recommendations, and no cautions discussed.

    2016
    Safety & Cautions

    Side Effects

    • Mild increase in LDL cholesterol at higher doses
    • Gastrointestinal discomfort
    • Headache
    Pterostilbene is generally well-tolerated in human studies at typical supplement doses. However, some research has noted modest LDL cholesterol elevations at higher intakes, so individuals with dyslipidemia should monitor lipid panels when supplementing.
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