SAMe

Morning on an empty stomach

S-adenosyl-L-methionine (SAMe) is a compound naturally produced in the body from the amino acid methionine and ATP. It serves as a primary methyl donor in hundreds of biochemical reactions and is concentrated in the liver and brain. SAMe is widely studied for its roles in mood regulation, joint health, and liver support.

Research Evidence

May improve symptoms of fibromyalgia

Limited

Supports methylation processes involved in neurotransmitter production

Moderate

Alleviates osteoarthritis pain comparable to some NSAIDs

Strong

Reduces symptoms of mild-to-moderate depression

Strong

Supports liver function in chronic liver conditions

Moderate

Source: Examine.com

Expert Evidence

1 reference from 1 expert

Discusses

“SAMe has been shown head to head with drugs like Naproxen to work at least as well as some of those compounds at certain doses for various forms of pain due to osteoarthritis or injury.”

Unknown Title

1:13:05

Andrew Huberman

1 reference in 1 episode from 2021

AI-generated summary

Huberman highlights SAMe as a supplement that has performed comparably to drugs like Naproxen in head-to-head studies for pain relief from osteoarthritis or injury. He does not mention personal use, specific dosing, or any cautions.

2021

Safety & Cautions

Side Effects

Nausea or digestive upset
Anxiety or restlessness at higher doses
Insomnia if taken late in the day
Dry mouth

SAMe should not be combined with serotonergic medications such as SSRIs or MAOIs without medical supervision due to the risk of serotonin syndrome. It is also not recommended for individuals with bipolar disorder, as it may trigger manic episodes.

Pairs Well With

Omega-3 Fatty Acids (EPA)Vitamin D3 Magnesium

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