Spermidine
Varies
Spermidine is a naturally occurring polyamine found in high concentrations in aged cheese, wheat germ, soybeans, and mushrooms. It has gained significant research interest for its ability to trigger autophagy — the cellular process that clears damaged proteins and organelles. Spermidine levels decline with age, which has led to investigation of both dietary and supplemental approaches to maintaining adequate levels.
Research Evidence
May support cognitive function and memory in aging adults
LimitedMay enhance immune cell function through improved mitochondrial health
LimitedInduces cellular autophagy and supports cellular recycling
StrongExtended lifespan and improved cardiac function in animal models
ModerateAssociated with reduced cardiovascular mortality in observational studies
ModerateExpert Evidence
9 references from 1 expert
2022
2021
Safety & Cautions
Side Effects
- Mild gastrointestinal discomfort
- Nausea at higher doses
- Allergic reactions in wheat-sensitive individuals
Spermidine from wheat germ extract is generally well-tolerated at typical doses, but individuals with wheat allergies or celiac disease should choose non-wheat-derived forms. As with any autophagy-promoting compound, those undergoing cancer treatment should consult their physician before supplementing.
Pairs Well With
Price Comparison
From $0.14/ct
L
LongLifeNutriBest Value
4.4
•180 ct$0.14/ct
$25.97 total
N
Neurogan
4.4
•120 ct$0.17/ct
$20.95 total
B
Black Forest
4.5
•120 ct$0.25/ct
$29.95 total
D
Double Wood Supplements
4.4
•120 ct$0.33/ct
$39.95 total
S
SUNAURA
4.8
•60 ct$0.42/ct
$24.99 total
T
Toniiq
4.4
•30 ct$0.83/ct
$24.97 total