Spermidine
Spermidine is a naturally occurring polyamine found in high concentrations in aged cheese, wheat germ, soybeans, and mushrooms. It has gained significant research interest for its ability to trigger autophagy — the cellular process that clears damaged proteins and organelles. Spermidine levels decline with age, which has led to investigation of both dietary and supplemental approaches to maintaining adequate levels.
Expert Evidence
2 references from 1 expert
“Personally I don't take spermidine supplements and instead focus on a great diet. We put mice on spermidine for eight weeks and six months and saw no increase in spermidine in the blood, liver, or any other tissues.”
Why You Should STOP Buying Spermidine Supplements
3:252 references in 2 episodes from 2021–2022
Stanfield acknowledges spermidine's promising animal data—stopping age-related heart decline and extending mouse lifespan by 10%—but recommends against supplementing it. He cites his own mouse studies showing no increase in spermidine levels in blood, liver, or other tissues after 8 weeks or 6 months of supplementation, and instead focuses on obtaining it through diet. No dosing guidance or cautions beyond inefficacy are discussed.
Side Effects
- Mild gastrointestinal discomfort
- Nausea at higher doses
- Allergic reactions in wheat-sensitive individuals
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