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Aspirin

With food

Aspirin (acetylsalicylic acid) is one of the oldest and most widely used medications, originally derived from willow bark. It belongs to the NSAID class and is used at various doses for pain relief, fever reduction, anti-inflammatory effects, and cardiovascular protection.

Andrew Huberman
Andrew HubermanReported use
Brad Stanfield
Brad StanfieldStopped
Research Evidence
Effective for short-term pain and fever relief
Strong
Anti-inflammatory effects may benefit chronic inflammatory conditions
Moderate
May have protective effects against certain other cancers
Limited
Does not provide clear benefit for primary cardiovascular prevention in healthy adults
Strong
May reduce risk of colorectal cancer with long-term use
Moderate
Reduces risk of recurrent heart attack and stroke in those with established cardiovascular disease
Strong
Source: Examine.com

Expert Evidence

31 references from 2 experts

“I personally like to avoid taking painkillers unless I have to take them. I might take an aspirin every once in a while, but I really like to avoid taking painkillers.”

Protocols to Strengthen & Pain Proof Your Back

1:12:48

7 references in 6 episodes from 2021–2025

Safety & Cautions

Side Effects

  • Gastrointestinal bleeding and ulcers
  • Increased bruising and bleeding tendency
  • Stomach pain and nausea
  • Tinnitus at high doses
  • Allergic reactions in aspirin-sensitive individuals
Aspirin carries meaningful bleeding risks including gastrointestinal and intracranial hemorrhage, especially with long-term use. It should only be taken regularly under medical guidance, and is contraindicated in children with viral illness due to the risk of Reye's syndrome.
Pairs Well With
Omega-3 Fatty Acids (EPA)Vitamin D3