Longevity Supplements

BS

"A meta-analysis... found that all 10 randomized controlled trials showed improvements in skin health including moisture, elasticity, and wrinkle number."

BS

"We've got fantastic evidence from randomized control trials showing that if we supplement with hyaluronic acid we reduce skin wrinkles by about 18%."

GC

"Randomized trials and meta-analyses generally show that berberine can help lower cholesterol, fasting glucose, triglycerides, blood pressure, and body weight."

BS

"In human clinical studies, pure resveratrol improves blood sugar levels, good cholesterol, blood pressure, kidney filtration and fatty liver."

RP

"The top 20% of consumers of cruciferous vegetables reduce their all-cause mortality by 22%."

BS

"In a clinical trial lasting 9 months, no one in the curcumin group had progressed to type 2 diabetes, compared to 16.4% of those in the placebo group."

BS

"After 12 months, the group who took vitamin B3 had a 23% lower rate of new skin cancers compared to the placebo group."

BS

"There is one supplement however that does have good evidence for boosting testosterone plus athletic performance, and it's betaine or TMG."

BS

"I continue to take taurine supplements, especially since a new human study of 1,394 people was just published on the 23rd of November, 2025 that reinforces my decision."

BS

"Alpha lipoic acid treatment coincided with a statistically significant 1.27 kg greater weight loss compared to placebo."

BS

"Taking daily Aspirin cut your long-term risk of dying from cancer by about a third, according to an analysis of eight randomized controlled trials and over 25,000 patients."

BS

"Glycine signals to the blood vessels to open up and dilate, which helps the body to lose heat and lowers our core body temperature. This drop in body temperature is a central part of the circadian shift into sleep."

RP

"Specifically using calcium vitamin D was associated with a 44% lower risk of dementia."

AH

"L-carnitine and acetyl-L-carnitine in particular facilitates fat oxidation. It helps convert fatty acids into ATP. Supplementing L-carnitine can increase fat loss."

BS

"This amino acid is critical for muscle building and maintenance."

BS

"We've got overwhelming human evidence that yes, NMN supplements, they do boost blood NAD."

GC

"Catechins can help with weight loss and specifically losing visceral fat. It's been shown in randomized controlled trials."

BS

"Astaxanthin powerfully activates an enzyme called NRF2, and NRF2 acts as a switch to activate a whole battery of antioxidant genes."

AH

"When I take NR and NMN at the dosages I talked about a little bit earlier, it gives me a lot of sustained mental and physical energy throughout the day."

AH

"NAC prevented the symptomatic forms caused by the H1N1 influenza virus quite efficiently. Only 25% in the NAC group developed disease versus 79% in the placebo group."

GC

"Methylene blue can act as a smart drug. It can improve your mind, your memory, and your learning."

BS

"It's a powerful antioxidant, but as we reach the age of 45, our levels of glutathione go down."

AH

"He very quickly moved from that animal model into human patients and started injecting human patients with lithium or providing lithium orally to those patients. And lo and behold, found an absolutely profound and positive effect of lithium in reducing symptoms of mania."

GC

"Lutein and zeaxanthin have some really great evidence for eye health and cognitive health."

BS

"The headline finding is that this combination of senolytics [dasatinib and quercetin] reduced the senescent cell burden within 11 days."

BS

"It's essential for our mitochondria's function. CoQ10 is also known to have antioxidant properties and it's found in high concentrations in the heart, liver and kidney."

BS

"Out of the 10 molecules tested, fisetin was the most potent senolytic. When fisetin was given to inbred mice, it extended their median as well as maximum lifespan."

SS

"Ketones are used as fuel just like amino acids. They are preferentially used by the brain for delaying fatigue and reducing the overall catabolic stress that occurs during exercise."

BS

"Giving spermidine as a supplement to mice, it stops the age-related decline in cardiovascular or heart function and it increases overall lifespan by 10%."

BS

"Lion's mane has shown some exciting effects in the lab where it encouraged nerve regrowth, which is incredibly exciting because it's vital to find ways to prevent and treat brain decline."

AH

"One of the best ways to support the thyroid system and metabolism in general is to make sure you're getting enough selenium. Brazil nuts, one or two or three of those per day, you'll have more than enough selenium."

BS

"In 2020, researchers at the Buck Institute published a study showing that AKG extended lifespan by nearly 17% and reduced frailty by 41 to 46% in mice."

BS

"Personally, I don't take DHEA nor do I recommend it to my patients."

BS

"A new paper published in March of 2022 showed that the combination of glycine and NAC supplementation in mice extended their lifespan by a whopping 24%."

RP

"Pterostilbene has been shown to activate the gene P P R alpha and has been shown to lower triglyceride and blood glucose level in mice."

AH

"I do that mainly for its effects on vascular function and blood flow and a few other effects that grape seed extract has been related to."

BS

"There's also anti-inflammatory supplements such as CoQ10 and PQQ... we don't want to interfere with that process [inflammation after exercise]."

BS

"Beta-hydroxybutyrate is a major metabolic product of ketogenic diets and they have been reported to increase survival and improved pathologies."

RP

"Ben Flamin I'm taking that by life extension."

RP

"My son eats about two cups of pomegranate a day so his Urolithin A levels must be off the charts and maybe he'll live to be 100."