Digestive Enzymes

Digestive enzymes are a group of proteins — primarily protease, lipase, and amylase — that catalyze the breakdown of macronutrients into absorbable molecules. They are naturally produced by the pancreas, stomach, and small intestine, but can be supplemented to support digestion when endogenous production is insufficient. Supplemental forms are typically derived from animal pancreas (pancreatin) or fungal/plant sources like bromelain and papain.

Research Evidence

May reduce symptoms of lactose intolerance when lactase is included

Strong

Potential anti-inflammatory effects from proteolytic enzymes like bromelain

Limited

Enhances nutrient absorption when endogenous enzyme output is low

Moderate

Improves fat and protein digestion in pancreatic insufficiency

Strong

Reduces postprandial bloating and gas in functional dyspepsia

Moderate

Expert Evidence

2 references from 2 experts

“If you have lactose intolerance, there are a number of strategies that are backed by science. There are lactose-free milks, there are lactase supplements, there's fermented dairy like yogurt.”

Pro Scientist fact-checks RAW MILK fad (with EVIDENCE)

7:58

2021

Safety & Cautions

Side Effects

Nausea at high doses
Abdominal cramping
Diarrhea
Allergic reactions in those sensitive to porcine or fungal sources

Digestive enzymes are generally well-tolerated at recommended doses. People with known allergies to pork or mold should check the enzyme source, and those on blood thinners should consult a physician before taking bromelain-containing formulas due to its mild fibrinolytic activity.

Pairs Well With

Probiotics

Price Comparison

From $0.05/ct

H

HorbäachBest Value

4.6

•250 ct

$0.05/ct

$13.29 total

Buy

N