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    Digestive Enzymes

    Digestive enzymes are a group of proteins — primarily protease, lipase, and amylase — that catalyze the breakdown of macronutrients into absorbable molecules. They are naturally produced by the pancreas, stomach, and small intestine, but can be supplemented to support digestion when endogenous production is insufficient. Supplemental forms are typically derived from animal pancreas (pancreatin) or fungal/plant sources like bromelain and papain.

    Research Evidence
    May reduce symptoms of lactose intolerance when lactase is included
    Strong
    Potential anti-inflammatory effects from proteolytic enzymes like bromelain
    Limited
    Enhances nutrient absorption when endogenous enzyme output is low
    Moderate
    Improves fat and protein digestion in pancreatic insufficiency
    Strong
    Reduces postprandial bloating and gas in functional dyspepsia
    Moderate

    Expert Evidence

    1 reference from 1 expert

    Currently takes

    “I take a couple digestive enzymes when I eat.”

    Andrew Huberman's Longevity Routine (supplements, diet, peptides, and exercise regimen)

    9:22
    Andrew Huberman

    1 reference in 1 episode from 2024

    AI-generated summary

    Huberman mentions taking digestive enzymes with meals but provides no specific brand, dosage, or timing details. No benefits, mechanisms, or cautions are discussed — this is a brief mention of personal use only.

    2024
    Safety & Cautions

    Side Effects

    • Nausea at high doses
    • Abdominal cramping
    • Diarrhea
    • Allergic reactions in those sensitive to porcine or fungal sources
    Digestive enzymes are generally well-tolerated at recommended doses. People with known allergies to pork or mold should check the enzyme source, and those on blood thinners should consult a physician before taking bromelain-containing formulas due to its mild fibrinolytic activity.
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