Grape Seed Extract
Grape seed extract is derived from the seeds of Vitis vinifera (wine grapes) and is one of the richest dietary sources of proanthocyanidins, a class of polyphenolic compounds. It has been widely studied for its cardiovascular-protective properties, particularly its ability to support healthy blood pressure and vascular function. The extract is commonly standardized to contain 90-95% proanthocyanidins.
Research Evidence
May improve chronic venous insufficiency symptoms
ModerateReduces markers of oxidative stress
ModerateMay reduce LDL oxidation
LimitedReduces systolic and diastolic blood pressure
StrongImproves endothelial function and blood flow
ModerateExpert Evidence
3 references from 1 expert
2023
2021
Safety & Cautions
Side Effects
- Mild nausea
- Headache
- Dizziness
- Stomach upset in sensitive individuals
Grape seed extract is generally well-tolerated at standard doses. Those taking blood thinners or antiplatelet medications should consult a healthcare provider, as proanthocyanidins may have mild anticoagulant effects.
Pairs Well With
Price Comparison
From $0.07/ct
C
CarlyleBest Value
4.6
•240 ct$0.07/ct
$17.89 total
N
Nutricost
4.7
•240 ct$0.08/ct
$19.95 total
N
NOW Foods
4.6
•200 ct$0.11/ct
$21.35 total
Z
Zazzee
4.6
•180 ct$0.14/ct
$24.97 total
O
Olympian Labs
4.4
•100 ct$0.20/ct
$19.63 total
Q
Qunol
4.5
•60 ct$0.28/ct
$16.61 total
A
Allergy Research Group
4.8
•90 ct$0.40/ct
$35.59 total
L
Life Extension
4.7
•60 ct$0.45/ct
$27.00 total