Phosphatidylserine
Phosphatidylserine is a phospholipid naturally found in high concentrations in brain cell membranes, where it plays a critical role in cell signaling and membrane fluidity. It is commercially derived from soy or sunflower lecithin and has been extensively studied for its effects on cognitive function, stress response, and age-related mental decline.
Expert Evidence
1 reference from 1 expert
“Both phosphatidylserine and phosphatidylethanolamine accumulate in mitochondrial membranes as well as cell membranes and they have been shown to decrease in concentration with age. Their decreasing concentration has been shown to play a role in neurodegenerative diseases.”
The Phospholipid Brain-DHA Advantage
9:441 reference in 1 episode from 2014
Rhonda Patrick discusses phosphatidylserine in the context of aging and neurodegeneration, noting that it accumulates in both mitochondrial and cell membranes and that its concentration decreases with age, contributing to neurodegenerative diseases. There is no evidence of personal use, no dosing recommendations, and no cautions discussed.
Side Effects
- Mild digestive discomfort at higher doses
- Insomnia when taken late in the day
- Nausea in sensitive individuals
$0.17/ct
$20.95 total
$0.20/ct
$23.95 total
$0.35/ct
$21.01 total