Phosphatidylserine

Phosphatidylserine is a phospholipid naturally found in high concentrations in brain cell membranes, where it plays a critical role in cell signaling and membrane fluidity. It is commercially derived from soy or sunflower lecithin and has been extensively studied for its effects on cognitive function, stress response, and age-related mental decline.

Andrew HubermanReported use

Research Evidence

May improve sleep quality under stressful conditions

Limited

Supports exercise recovery by reducing muscle soreness markers

Moderate

Supports memory and cognitive function in older adults

Strong

May improve attention and reduce impulsivity in children

Moderate

Blunts cortisol response to physical and mental stress

Strong

Source: Examine.com

Expert Evidence

5 references from 1 expert

“Typically, if I leveraged other forms of pharmacology in order to enhance learning and memory, things like phosphatidyl serine, I would do that by taking those things before I sat down to learn a particular set of information.”

Understand & Improve Memory Using Science-Based Tools

56:45

5 references in 4 episodes from 2021–2025

2025

2022

2021

Safety & Cautions

Side Effects

Mild digestive discomfort at higher doses
Insomnia when taken late in the day
Nausea in sensitive individuals

Phosphatidylserine is generally well-tolerated at standard doses up to 300 mg daily. Those taking blood-thinning medications or anticholinergic drugs should consult a healthcare provider before use, as phosphatidylserine may interact with these medications.

Pairs Well With

Alpha-GPC

Price Comparison

From $0.14/ct

D

Double WoodBest Value

4.5

•120 ct

$0.14/ct

$16.96 total

Buy

N