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    Phosphatidylserine

    Phosphatidylserine is a phospholipid naturally found in high concentrations in brain cell membranes, where it plays a critical role in cell signaling and membrane fluidity. It is commercially derived from soy or sunflower lecithin and has been extensively studied for its effects on cognitive function, stress response, and age-related mental decline.

    Andrew Huberman
    Andrew HubermanTakes it
    Research Evidence
    May improve sleep quality under stressful conditions
    Limited
    Supports exercise recovery by reducing muscle soreness markers
    Moderate
    Supports memory and cognitive function in older adults
    Strong
    May improve attention and reduce impulsivity in children
    Moderate
    Blunts cortisol response to physical and mental stress
    Strong
    Source: Examine.com

    Expert Evidence

    4 references from 1 expert

    “Typically, if I leveraged other forms of pharmacology in order to enhance learning and memory, things like phosphatidyl serine, I would do that by taking those things before I sat down to learn a particular set of information.”

    Understand & Improve Memory Using Science-Based Tools

    56:45
    2025
    2022
    2021
    Safety & Cautions

    Side Effects

    • Mild digestive discomfort at higher doses
    • Insomnia when taken late in the day
    • Nausea in sensitive individuals
    Phosphatidylserine is generally well-tolerated at standard doses up to 300 mg daily. Those taking blood-thinning medications or anticholinergic drugs should consult a healthcare provider before use, as phosphatidylserine may interact with these medications.
    Pairs Well With
    Alpha-GPC
    Price Comparison
    From $0.15/ct
    D
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    4.5
    •120 ct

    $0.15/ct

    $17.81 total

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    N
    Nutricost
    4.5
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    $0.20/ct

    $23.95 total

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    N
    NOW Foods
    4.6
    •60 ct

    $0.36/ct

    $21.38 total

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