TMG (Trimethylglycine)

With meals

Trimethylglycine (TMG), also known as betaine, is a naturally occurring compound found in foods like beets, spinach, and quinoa. It serves as one of the body's primary methyl donors, playing a central role in methylation reactions and homocysteine metabolism. TMG is widely used to support cardiovascular health markers and is a common companion supplement to NAD+ precursors like NMN and NR.

Brad StanfieldTakes it

Research Evidence

May lower a risk factor for Alzheimer's disease by reducing homocysteine

Limited

Promotes cellular hydration through osmolyte activity

Moderate

Reduces elevated homocysteine levels

Strong

Supports methylation reactions as a methyl donor

Strong

May improve resistance exercise performance and power output

Moderate

Source: Examine.com

Expert Evidence

37 references from 1 expert

“I wanted to include TMG or trimethylglycine to try and combine some of the supplements that I was already taking.”

I Refuse to Let You Down

1:41

Safety & Cautions

Side Effects

Gastrointestinal discomfort at high doses
Diarrhea (osmotic effect at very high doses)
Possible increase in total and LDL cholesterol at high doses
Fishy body odor in rare cases

TMG is generally well tolerated at typical supplemental doses. Those with existing cholesterol concerns should monitor lipid levels if using higher doses (above 3 g/day), and individuals on medications affecting homocysteine metabolism should consult a healthcare provider.

Pairs Well With

NMN Vitamin B12 Creatine

Price Comparison

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