TMG (Trimethylglycine)
With meals
Trimethylglycine (TMG), also known as betaine, is a naturally occurring compound found in foods like beets, spinach, and quinoa. It serves as one of the body's primary methyl donors, playing a central role in methylation reactions and homocysteine metabolism. TMG is widely used to support cardiovascular health markers and is a common companion supplement to NAD+ precursors like NMN and NR.
Research Evidence
May lower a risk factor for Alzheimer's disease by reducing homocysteine
LimitedPromotes cellular hydration through osmolyte activity
ModerateReduces elevated homocysteine levels
StrongSupports methylation reactions as a methyl donor
StrongMay improve resistance exercise performance and power output
ModerateExpert Evidence
37 references from 1 expert
“I wanted to include TMG or trimethylglycine to try and combine some of the supplements that I was already taking.”
I Refuse to Let You Down
1:4137 references in 27 episodes from 2022–2025
Safety & Cautions
Side Effects
- Gastrointestinal discomfort at high doses
- Diarrhea (osmotic effect at very high doses)
- Possible increase in total and LDL cholesterol at high doses
- Fishy body odor in rare cases
TMG is generally well tolerated at typical supplemental doses. Those with existing cholesterol concerns should monitor lipid levels if using higher doses (above 3 g/day), and individuals on medications affecting homocysteine metabolism should consult a healthcare provider.
Pairs Well With
Price Comparison
From $0.06/ct
D
Double WoodBest Value
4.6
•180 ct$0.06/ct
$11.35 total
N
Nutricost
4.5
•120 ct$0.08/ct
$9.95 total
S
Swanson
4.4
•90 ct$0.12/ct
$11.09 total
N
NOW Foods
4.4
•100 ct$0.43/ct
$42.99 total
L
Life Extension
4.5
•100 ct$0.20/ct
$19.95 total
1
10X Health System
4.6
•60 ct$0.42/ct
$25.00 total