NMN

Nicotinamide mononucleotide (NMN) is a naturally occurring nucleotide and direct precursor to NAD+, a coenzyme essential for cellular energy metabolism, DNA repair, and sirtuin activation. Found in trace amounts in foods like edamame, broccoli, and avocado, NMN has gained attention in longevity research for its potential to restore declining NAD+ levels associated with aging.

Andrew HubermanTakes it

Brad StanfieldStopped

Research Evidence

May improve markers of aerobic capacity in older adults

Moderate

Potential to improve sleep quality in older adults

Limited

May support insulin sensitivity

Moderate

May slow biological markers of aging

Limited

Increases blood NAD+ levels

Strong

Potential neuroprotective effects

Limited

Source: Examine.com

Expert Evidence

22 references from 4 experts

“I confess I take NMN powder. I don't have any belief that it's going to increase my lifespan, but it seems to have a pro energy effect that I like.”

Restore Youthfulness & Vitality to the Aging Brain & Body | Dr. Tony Wyss-Coray

33:43

Safety & Cautions

Side Effects

Mild gastrointestinal discomfort
Flushing
Headache
Nausea at higher doses

NMN is generally well-tolerated in human studies at doses up to 1200 mg daily for several weeks. However, there is theoretical concern that boosting NAD+ could fuel growth of existing cancers, so individuals with active malignancies or a history of cancer should consult their physician before supplementing.

Pairs Well With

Resveratrol Vitamin D3 CoQ10 Omega-3 Fatty Acids (EPA)

Price Comparison

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