NMN
Nicotinamide mononucleotide (NMN) is a naturally occurring nucleotide and direct precursor to NAD+, a coenzyme essential for cellular energy metabolism, DNA repair, and sirtuin activation. Found in trace amounts in foods like edamame, broccoli, and avocado, NMN has gained attention in longevity research for its potential to restore declining NAD+ levels associated with aging.
Research Evidence
May improve markers of aerobic capacity in older adults
ModeratePotential to improve sleep quality in older adults
LimitedMay support insulin sensitivity
ModerateMay slow biological markers of aging
LimitedIncreases blood NAD+ levels
StrongPotential neuroprotective effects
LimitedExpert Evidence
24 references from 4 experts
Safety & Cautions
Side Effects
- Mild gastrointestinal discomfort
- Flushing
- Headache
- Nausea at higher doses
NMN is generally well-tolerated in human studies at doses up to 1200 mg daily for several weeks. However, there is theoretical concern that boosting NAD+ could fuel growth of existing cancers, so individuals with active malignancies or a history of cancer should consult their physician before supplementing.
Pairs Well With