Benfotiamine
Benfotiamine is a synthetic, lipid-soluble form of vitamin B1 (thiamine) that achieves significantly higher blood and tissue levels compared to standard thiamine supplements. Originally developed in Japan, it has been widely used in Europe for decades to address conditions linked to thiamine deficiency. It is particularly studied for its effects on nerve function, blood sugar metabolism, and protection against advanced glycation end products (AGEs).
Research Evidence
May reduce oxidative stress markers related to glucose metabolism
ModerateMay help reduce markers of advanced glycation end products (AGEs)
ModerateAchieves higher bioavailability than standard thiamine
StrongSupports peripheral nerve function in those with metabolic concerns
ModeratePotential benefit for alcohol-related thiamine deficiency
LimitedExpert Evidence
1 reference from 1 expert
“Ben Flamin I'm taking that by life extension.”
This Is Everything Rhonda Patrick Supplements With
0:481 reference in 1 episode from 2024
2024
Safety & Cautions
Side Effects
- Mild gastrointestinal discomfort
- Skin rash in rare cases
- Headache at higher doses
Benfotiamine is generally well-tolerated at standard doses with a strong safety profile across clinical studies. Those who are pregnant, nursing, or taking medications that interact with B vitamins should consult a healthcare provider before supplementing.
Pairs Well With
Price Comparison
From $0.08/ct
N
NutricostBest Value
4.7
•120 ct$0.08/ct
$9.99 total
D
Doctor's Best
4.6
•60 ct$0.30/ct
$17.99 total
L
Life Extension
5
•120 ct$0.53/ct
$63.65 total
P
Pure Encapsulations
4.7
•90 ct$0.66/ct
$59.00 total