Fisetin
Fisetin is a naturally occurring flavonoid polyphenol found in high concentrations in strawberries, with smaller amounts in apples, persimmons, onions, and grapes. It has gained attention in longevity research for its potential senolytic properties — the ability to selectively clear senescent (damaged, non-dividing) cells that accumulate with aging. While preclinical studies are promising, human clinical evidence remains early-stage.
Expert Evidence
2 references from 1 expert
“I also used to take NMN, quercetin, and fisetin, all of which I've stopped because the current research suggests that there's no added benefit beyond a placebo.”
Why Many People Are Abandoning Intermittent Fasting
10:052 references in 2 episodes from 2022–2023
Brad Stanfield previously took fisetin as a senolytic to clear senescent cells but has since stopped, concluding that current research shows no benefit beyond placebo. No dosage details, timing guidance, or specific cautions were discussed.
Side Effects
- Mild gastrointestinal discomfort
- Nausea at higher doses
- Possible diarrhea
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