Fisetin
Varies
Varies
Fisetin is a naturally occurring flavonoid polyphenol found in high concentrations in strawberries, with smaller amounts in apples, persimmons, onions, and grapes. It has gained attention in longevity research for its potential senolytic properties — the ability to selectively clear senescent (damaged, non-dividing) cells that accumulate with aging. While preclinical studies are promising, human clinical evidence remains early-stage.
Research Evidence
May selectively clear senescent cells in preclinical models
LimitedDemonstrates antioxidant and anti-inflammatory activity in cell studies
ModerateReduces markers of inflammation in preclinical research
ModerateMay support neuroprotective pathways in animal models of cognitive decline
LimitedExtended lifespan and healthspan in aged mice
LimitedExpert Evidence
6 references from 1 expert
2025
2023
2022
Safety & Cautions
Side Effects
- Mild gastrointestinal discomfort
- Nausea at higher doses
- Possible diarrhea
Fisetin is generally well-tolerated at typical supplement doses, though long-term safety data in humans is limited. Those on blood-thinning medications or undergoing cancer treatment should consult a physician, as fisetin may interact with certain drug-metabolizing enzymes.
Pairs Well With
Price Comparison
From $0.18/ct
C
CarlyleBest Value
4.2
•90 ct$0.18/ct
$16.64 total
N
Nutricost
4.4
•60 ct$0.37/ct
$21.95 total
D
Double Wood Supplements
4.5
•60 ct$0.38/ct
$22.95 total
K
Kayseari
4.5
•60 ct$0.43/ct
$25.99 total
T
Toniiq
4.6
•60 ct$0.74/ct
$44.41 total
N
Neurogan
4.2
•30 ct$0.81/ct
$24.31 total