Glutamine
Glutamine is the most abundant free amino acid in the human body, produced primarily in skeletal muscle and circulated to organs with high demand like the gut and immune cells. It becomes conditionally essential during periods of intense physical stress, illness, or injury when the body's production may not keep pace with demand. It is widely used to support gut barrier function, immune resilience, and recovery from strenuous exercise.
Research Evidence
Helps maintain immune function during prolonged intense exercise
ModerateSupports gut barrier integrity and may reduce intestinal permeability
ModerateMay help reduce sugar and alcohol cravings
LimitedMay reduce duration and severity of infections in critically ill patients
ModerateSupports recovery after strenuous physical activity
LimitedExpert Evidence
16 references from 3 experts
Safety & Cautions
Side Effects
- Elevated blood ammonia at very high doses
- Mild gastrointestinal discomfort in some individuals
- Rare allergic reactions
Glutamine is generally well-tolerated at standard supplemental doses. However, individuals with a history of cancer or active tumors should consult a physician before supplementing, as some cancer cells preferentially utilize glutamine for growth.
Pairs Well With
Price Comparison
From $0.08/ct
D
Double WoodBest Value
4.6
•120 ct$0.08/ct
$9.95 total
N
Nutricost
4.5
•180 ct$0.09/ct
$15.95 total
O
Optimum Nutrition
4.4
•240 ct$0.09/ct
$20.99 total
N
NOW Foods
4.7
•120 ct$0.12/ct
$14.29 total
P
Pure Encapsulations
4.6
•90 ct$0.27/ct
$24.50 total
T
THORNE
4.6
•90 ct$0.29/ct
$26.00 total