Glutamine

Glutamine is the most abundant free amino acid in the human body, produced primarily in skeletal muscle and circulated to organs with high demand like the gut and immune cells. It becomes conditionally essential during periods of intense physical stress, illness, or injury when the body's production may not keep pace with demand. It is widely used to support gut barrier function, immune resilience, and recovery from strenuous exercise.

Andrew HubermanReported use

Rhonda PatrickReported use

Research Evidence

Helps maintain immune function during prolonged intense exercise

Moderate

Supports gut barrier integrity and may reduce intestinal permeability

Moderate

May help reduce sugar and alcohol cravings

Limited

May reduce duration and severity of infections in critically ill patients

Moderate

Supports recovery after strenuous physical activity

Limited

Source: Examine.com

Expert Evidence

19 references from 3 experts

“I've been taking glutamine for years and find it useful when feeling run down. There are decent data on its role in offsetting leaky gut and it can also be used to help reduce sugar cravings.”

Dr. Andy Galpin: Optimal Nutrition & Supplementation for Fitness | Huberman Lab Guest Series

2:31:56

15 references in 8 episodes from 2021–2025

Safety & Cautions

Side Effects

Elevated blood ammonia at very high doses
Mild gastrointestinal discomfort in some individuals
Rare allergic reactions

Glutamine is generally well-tolerated at standard supplemental doses. However, individuals with a history of cancer or active tumors should consult a physician before supplementing, as some cancer cells preferentially utilize glutamine for growth.

Pairs Well With

Zinc Probiotics Vitamin C

Price Comparison

From $0.08/ct

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Double WoodBest Value

4.6

•120 ct

$0.08/ct

$9.95 total

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