Lithium
5-20mg
With meals
Lithium is a naturally occurring trace mineral present in varying concentrations in drinking water, grains, and certain vegetables. While high-dose lithium carbonate is a well-established psychiatric medication, low-dose lithium (typically as lithium orotate) has gained interest for its potential neuroprotective and mood-supporting properties at much smaller doses.
Research Evidence
Associated with lower rates of dementia in populations with higher water lithium levels
ModerateMay reduce neuroinflammation and support brain health
ModerateSupports mood stabilization in bipolar disorder (prescription doses)
StrongPromotes BDNF expression and neuroplasticity
ModerateLow-dose supplementation may support emotional resilience and stress response
LimitedExpert Evidence
13 references from 3 experts
“Drugs that should absolutely not be taken during breastfeeding include lithium.”
The Biology of Breast Milk
19:511 reference in 1 episode from 2020
2025
2022
2020
Safety & Cautions
Side Effects
- Mild gastrointestinal discomfort
- Increased thirst
- Slight drowsiness at higher doses
- Potential thyroid suppression with long-term high-dose use
Low-dose lithium orotate is generally well-tolerated at recommended amounts, but individuals with thyroid or kidney conditions should consult a healthcare provider before supplementing. Lithium can interact with certain medications including diuretics, NSAIDs, and ACE inhibitors.
Pairs Well With