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    Lithium

    5-20mg
    With meals

    Lithium is a naturally occurring trace mineral present in varying concentrations in drinking water, grains, and certain vegetables. While high-dose lithium carbonate is a well-established psychiatric medication, low-dose lithium (typically as lithium orotate) has gained interest for its potential neuroprotective and mood-supporting properties at much smaller doses.

    Research Evidence
    Associated with lower rates of dementia in populations with higher water lithium levels
    Moderate
    May reduce neuroinflammation and support brain health
    Moderate
    Supports mood stabilization in bipolar disorder (prescription doses)
    Strong
    Promotes BDNF expression and neuroplasticity
    Moderate
    Low-dose supplementation may support emotional resilience and stress response
    Limited
    Source: Examine.com

    Expert Evidence

    8 references from 3 experts

    “Drugs that should absolutely not be taken during breastfeeding include lithium.”

    The Biology of Breast Milk

    19:51
    2025
    2022
    2020
    Safety & Cautions

    Side Effects

    • Mild gastrointestinal discomfort
    • Increased thirst
    • Slight drowsiness at higher doses
    • Potential thyroid suppression with long-term high-dose use
    Low-dose lithium orotate is generally well-tolerated at recommended amounts, but individuals with thyroid or kidney conditions should consult a healthcare provider before supplementing. Lithium can interact with certain medications including diuretics, NSAIDs, and ACE inhibitors.
    Pairs Well With
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