Lithium
Lithium is a naturally occurring trace mineral present in varying concentrations in drinking water, grains, and certain vegetables. While high-dose lithium carbonate is a well-established psychiatric medication, low-dose lithium (typically as lithium orotate) has gained interest for its potential neuroprotective and mood-supporting properties at much smaller doses.
Expert Evidence
3 references from 1 expert
“Lithium increases BDNF, which creates a kind of buoyancy to neuroplasticity and opens the gates to neuroplasticity.”
The Science & Treatment of Bipolar Disorder
1:07:283 references in 1 episode from 2022
Huberman highlights lithium's neuroprotective benefits across three mechanisms: reducing neural inflammation, increasing BDNF to support neuroplasticity, and preserving neural circuits involved in interoception and emotional regulation in bipolar depression treatment. All three references focus on therapeutic benefits with no mention of personal use, specific dosing, supplement form (e.g., lithium orotate vs. carbonate), or cautions.
Side Effects
- Mild gastrointestinal discomfort
- Increased thirst
- Slight drowsiness at higher doses
- Potential thyroid suppression with long-term high-dose use
$0.10/ct
$5.99 total
$0.10/ct
$18.00 total