Inositol

Inositol is a naturally occurring carbocyclic sugar found in fruits, beans, grains, and nuts that plays a critical role in cellular signaling pathways. The most commonly supplemented form, myo-inositol, acts as a second messenger in insulin and serotonin receptor systems. It has gained significant attention for its effects on mood regulation, anxiety reduction, and metabolic health.

Andrew HubermanReported use

Rhonda PatrickReported use

Research Evidence

May help reduce symptoms of obsessive-compulsive disorder

Moderate

Reduces anxiety symptoms with potency comparable to some prescription medications

Strong

Supports overall mood stability and emotional regulation

Moderate

Improves insulin sensitivity and metabolic markers in PCOS

Strong

Supports falling back asleep and overall sleep quality

Moderate

Source: Examine.com

Expert Evidence

34 references from 2 experts

“I find that if I wake up in the middle of the night and I've taken 900 milligrams of myo-inositol before initially falling asleep, I fall back asleep much more easily. It is especially effective for enhancing sleep when ingesting fewer carbohydrates.”

Dr. Andy Galpin: Optimal Nutrition & Supplementation for Fitness | Huberman Lab Guest Series

2:17:00

33 references in 14 episodes from 2021–2025

Safety & Cautions

Side Effects

Mild gastrointestinal discomfort at high doses
Nausea
Bloating or gas
Loose stools

Inositol is generally well-tolerated even at high doses, though gastrointestinal side effects are more common above 12 grams per day. Those taking psychiatric medications or blood sugar-lowering drugs should consult a healthcare provider before supplementing, as inositol may interact with these pathways.

Pairs Well With

Magnesium L-Theanine Omega-3 Fatty Acids (EPA)Vitamin D3

Price Comparison

From $0.09/ct

N

NOW Foods Inositol 500mgBest Value

4.7

•200 ct

$0.09/ct

$18.85 total

Buy

P