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    Inositol

    Inositol is a naturally occurring carbocyclic sugar found in fruits, beans, grains, and nuts that plays a critical role in cellular signaling pathways. The most commonly supplemented form, myo-inositol, acts as a second messenger in insulin and serotonin receptor systems. It has gained significant attention for its effects on mood regulation, anxiety reduction, and metabolic health.

    Andrew Huberman
    Andrew HubermanTakes it
    Rhonda Patrick
    Rhonda PatrickTakes it
    Research Evidence
    May help reduce symptoms of obsessive-compulsive disorder
    Moderate
    Reduces anxiety symptoms with potency comparable to some prescription medications
    Strong
    Supports overall mood stability and emotional regulation
    Moderate
    Improves insulin sensitivity and metabolic markers in PCOS
    Strong
    Supports falling back asleep and overall sleep quality
    Moderate
    Source: Examine.com

    Expert Evidence

    29 references from 2 experts

    “I find that if I wake up in the middle of the night and I've taken 900 milligrams of myo-inositol before initially falling asleep, I fall back asleep much more easily. It is especially effective for enhancing sleep when ingesting fewer carbohydrates.”

    Dr. Andy Galpin: Optimal Nutrition & Supplementation for Fitness | Huberman Lab Guest Series

    2:17:00
    Safety & Cautions

    Side Effects

    • Mild gastrointestinal discomfort at high doses
    • Nausea
    • Bloating or gas
    • Loose stools
    Inositol is generally well-tolerated even at high doses, though gastrointestinal side effects are more common above 12 grams per day. Those taking psychiatric medications or blood sugar-lowering drugs should consult a healthcare provider before supplementing, as inositol may interact with these pathways.
    Pairs Well With
    MagnesiumL-TheanineOmega-3 Fatty Acids (EPA)Vitamin D3
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    N
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    D
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    4.6
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    W
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