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Saffron

Morning

Saffron is a spice harvested from the stigmas of the Crocus sativus flower, native to Southwest Asia and widely cultivated in Iran. It has been used in traditional medicine for centuries and has gained attention in modern research for its mood-supporting and anxiolytic properties. The active compounds crocin and safranal are believed to be responsible for most of its therapeutic effects.

Research Evidence
May support appetite regulation
Limited
May lower anxiety scores on standardized rating scales
Moderate
May have antioxidant and neuroprotective properties
Limited
May reduce symptoms of mild to moderate low mood
Strong
May support healthy stress response
Moderate
Source: Examine.com

Expert Evidence

3 references from 1 expert

“There are 12 studies showing that orally ingested saffron is effective for reducing anxiety on standard inventories like the Hamilton Anxiety Rating Scale.”

Erasing Fears & Traumas Using Modern Neuroscience | Huberman Lab Essentials

32:10

3 references in 2 episodes from 2021–2025

2025
2021
Safety & Cautions

Side Effects

  • Dry mouth
  • Drowsiness
  • Nausea at higher doses
  • Headache
  • Appetite changes
At standard supplemental doses of 30 mg per day, saffron is generally well-tolerated with a mild side-effect profile. Pregnant women should avoid supplemental doses, as high amounts have historically been associated with uterine stimulation.
Pairs Well With
MagnesiumOmega-3 Fatty Acids (EPA)Vitamin D3L-Theanine