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    Vitamin B3

    With meals, split into two doses

    Vitamin B3 is an essential water-soluble nutrient found in meat, fish, legumes, and fortified grains. It exists in several supplemental forms—nicotinic acid (niacin), nicotinamide (niacinamide), and nicotinamide riboside—each with distinct physiological effects. It is best known for its central role in producing NAD+, a coenzyme critical to energy metabolism, DNA repair, and cellular signaling.

    Brad Stanfield
    Brad StanfieldTakes it
    Research Evidence
    Improves skin barrier function and reduces hyperpigmentation (nicotinamide)
    Moderate
    May reduce non-melanoma skin cancer risk (nicotinamide)
    Moderate
    May support mitochondrial biogenesis and muscle recovery
    Moderate
    Raises HDL cholesterol and lowers triglycerides (nicotinic acid form)
    Strong
    Supports NAD+ biosynthesis and cellular energy production
    Strong
    Source: Examine.com

    Expert Evidence

    40 references from 5 experts

    “Until we have that long-term research, I would not supplement with vitamin B3 in any form beyond 50 mg.”

    I read all 18 NMN Human Studies – 4 Key Findings

    13:11
    Safety & Cautions

    Side Effects

    • Skin flushing and warmth (nicotinic acid)
    • Nausea or stomach upset at high doses
    • Potential liver stress with sustained-release niacin
    • Headache
    High-dose nicotinic acid can elevate liver enzymes and should be monitored by a healthcare provider, especially in sustained-release formulations. Nicotinamide is generally well-tolerated at typical supplemental doses and does not cause flushing.
    Pairs Well With
    CoQ10Vitamin D3Omega-3 Fatty Acids (EPA)
    Price Comparison
    From $0.19/ct
    N
    NOW FoodsBest Value
    4.6
    •100 ct

    $0.19/ct

    $19.43 total

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