Alpha-Ketoglutarate (AKG)
Alpha-ketoglutarate (AKG) is a naturally occurring organic acid that serves as a key intermediate in the Krebs cycle, the central metabolic pathway cells use to generate energy. It is produced endogenously but declines with age, which has driven interest in supplemental forms—particularly calcium alpha-ketoglutarate (Ca-AKG)—for their potential anti-aging and metabolic benefits.
Expert Evidence
16 references from 2 experts
“I don't recommend alpha-ketoglutarate for everybody, but I do recommend it for athletes.”
The Science & Process of Healing From Grief
1:11:1111 references in 8 episodes from 2021–2025
Huberman's stance on alpha-ketoglutarate is mixed — he personally takes it and acknowledges its role in energy production and potential longevity benefits, but generally does not recommend it for most people, suggesting it may be more appropriate for athletes specifically.
Consumption
Huberman has stated he takes alpha-ketoglutarate as part of his supplement stack.
Benefits
He discusses AKG's involvement in the Krebs cycle and energy production, noting potential roles in exercise performance, longevity, and muscle protein synthesis.
Best Practices
A common dose is 1-2 grams, taken before workouts.
Cautions
Huberman generally does not recommend alpha-ketoglutarate for most people, though he makes an exception for athletes. He advises starting with a lower dose despite no significant reported side effects.
“People who took AKG showed statistically significant average reduction in their age of approximately eight years.”
How To Not Fall For USELESS Supplements!
3:575 references in 3 episodes from 2022–2024
Brad Stanfield highlights AKG's potential longevity benefits, citing mouse lifespan extension studies and a human retrospective analysis showing biological age reduction. There is no evidence of personal use, no specific dosing guidance, and no cautions discussed.
Benefits
AKG extended median lifespan in mice by 10.5-16.6% and a human retrospective analysis showed an average 8-year reduction in biological age as measured by DNA methylation clocks.
Side Effects
- Mild gastrointestinal discomfort
- Nausea at higher doses
- Diarrhea
- Bloating
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