Alpha-Ketoglutarate (AKG)
Alpha-ketoglutarate (AKG) is a naturally occurring organic acid that serves as a key intermediate in the Krebs cycle, the central metabolic pathway cells use to generate energy. It is produced endogenously but declines with age, which has driven interest in supplemental forms—particularly calcium alpha-ketoglutarate (Ca-AKG)—for their potential anti-aging and metabolic benefits.
Research Evidence
May extend healthspan in aging populations
ModerateSupports mitochondrial energy production
StrongMay improve exercise recovery and nitrogen balance
LimitedReduces biological age markers (epigenetic clocks)
ModerateSupports bone mineral density via calcium delivery
LimitedExpert Evidence
5 references from 2 experts
2023
2016
Safety & Cautions
Side Effects
- Mild gastrointestinal discomfort
- Nausea at higher doses
- Diarrhea
- Bloating
AKG is generally well-tolerated at commonly used doses. Individuals with kidney disease or calcium metabolism disorders should consult a healthcare provider before supplementing, particularly with the calcium-bound form.
Pairs Well With
Price Comparison
From $0.08/ct
N
NutricostBest Value
4.5
•240 ct$0.08/ct
$19.95 total
S
SMNutrition
4.6
•90 ct$0.16/ct
$13.95 total
D
Double Wood
4.3
•180 ct$0.17/ct
$29.95 total
L
LongJuvity
4.4
•60 ct$0.43/ct
$25.95 total
C
Codeage
4.8
•60 ct$0.50/ct
$29.99 total
R
Rejuvant
4.2
•60 ct$1.83/ct
$109.95 total