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Cannabidiol (CBD)

Evening or before bed

Cannabidiol (CBD) is a non-intoxicating compound derived from the Cannabis sativa plant. Unlike THC, it does not produce a euphoric high, making it one of the most widely studied cannabinoids for therapeutic applications. CBD is available in oils, capsules, gummies, and topical formulations, and has gained significant attention for its potential effects on anxiety, pain, and neurological conditions.

Research Evidence
May reduce symptoms of generalized and social anxiety
Moderate
May improve sleep quality and onset latency
Moderate
Potential neuroprotective effects in neurodegenerative conditions
Limited
May reduce chronic inflammatory and neuropathic pain
Limited
Reduces seizure frequency in treatment-resistant epilepsy
Strong
Source: Examine.com

Expert Evidence

8 references from 2 experts

“Avoiding cannabis use and maybe even CBD use within 8 to 12 hours of sleep can be very beneficial if your goal is to improve the quality of your sleep.”

AMA #2: Improve Sleep, Reduce Sugar Cravings, Optimal Protein Intake, Stretching Frequency & More

8:32

7 references in 6 episodes from 2021–2025

Safety & Cautions

Side Effects

  • Drowsiness or fatigue
  • Diarrhea
  • Changes in appetite
  • Dry mouth
  • Potential liver enzyme elevations at high doses
CBD can interact with several medications by inhibiting cytochrome P450 enzymes (particularly CYP3A4 and CYP2C19), so individuals taking prescription drugs—especially blood thinners, anti-epileptics, or immunosuppressants—should consult a healthcare provider before use. It is generally well-tolerated at moderate doses in most adults.
Pairs Well With
MagnesiumL-TheanineOmega-3 Fatty Acids (EPA)AshwagandhaMelatonin