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Glutathione

With meals

Glutathione is a tripeptide composed of glutamate, cysteine, and glycine that is synthesized in virtually every cell of the body. Often referred to as the master antioxidant, it plays a critical role in neutralizing reactive oxygen species, recycling other antioxidants like vitamins C and E, and supporting phase II liver detoxification. Oral supplementation has historically faced bioavailability challenges, leading to the development of liposomal and acetylated forms.

Research Evidence
Enhances immune cell function in older populations
Limited
Reduces markers of oxidative stress in aging adults
Moderate
May improve insulin sensitivity in individuals with metabolic dysfunction
Limited
Improves skin brightness and reduces melanin index
Moderate
Supports liver detoxification pathways
Moderate
Source: Examine.com

Expert Evidence

14 references from 2 experts

“Previous animal research had found that it's a precursor that boosts the levels of a key antioxidant called glutathione.”

The Most Important Antioxidant Study I’ve Ever Read

6:58

11 references in 8 episodes from 2021–2026

Safety & Cautions

Side Effects

  • Bloating or digestive discomfort at higher doses
  • Potential cramping with oral forms
  • Allergic reactions in rare cases
  • Concern about excessive cellular levels with liposomal forms bypassing normal regulation
Glutathione is generally well-tolerated at standard doses, but liposomal forms may bypass the body's normal regulatory mechanisms, so caution and medical guidance are warranted. People on chemotherapy or immunosuppressive medications should consult a physician before supplementing, as glutathione can influence drug metabolism.
Pairs Well With
N-Acetyl Cysteine (NAC)Vitamin CSeleniumAlpha Lipoic AcidGlycine