Hyaluronic Acid
Hyaluronic acid is a naturally occurring glycosaminoglycan found throughout the body, with the highest concentrations in skin, synovial joint fluid, and connective tissues. It has a remarkable capacity to bind water — a single molecule can hold up to 1,000 times its weight in moisture. Oral supplementation has gained attention for its potential to improve skin hydration, reduce visible signs of aging, and support joint comfort.
Expert Evidence
35 references from 1 expert
“We've got multiple randomized placebo-controlled studies in humans showing that hyaluronic acid is absorbed and it does improve aspects of skin health. Personally, I take 200 milligrams every day.”
The Supplements That ACTUALLY Work
1:3235 references in 29 episodes from 2022–2025
Brad Stanfield is a strong advocate for hyaluronic acid supplementation for skin health, citing multiple randomized controlled trials showing ~18% reductions in wrinkles. He takes it daily himself at 200mg. He has not discussed any cautions, side effects, or reasons to avoid it.
Consumption
He takes 200mg of hyaluronic acid daily as an oral supplement, and has used both high molecular weight and low molecular weight forms at different times.
Benefits
He consistently cites RCTs showing hyaluronic acid supplements improve skin hydration and reduce wrinkles by approximately 18.8% compared to placebo, noting that skin hyaluronic acid levels decline significantly with age.
Best Practices
He recommends 200mg daily, the most commonly used dose in clinical trials, and has used sodium hyaluronate in his Micro Vitamin formulation for enhanced stability and absorption.
Side Effects
- Mild digestive discomfort
- Bloating in some individuals
- Rare allergic reactions in those sensitive to avian-derived products
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