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Lion's Mane

500-1000mg
With meals

Lion's mane (Hericium erinaceus) is a large, white, shaggy edible mushroom that grows on hardwood trees and has been used in traditional East Asian medicine for centuries. It contains bioactive compounds called hericenones and erinacines that can cross the blood-brain barrier and are studied primarily for their neurological and cognitive benefits.

Research Evidence
Supports nerve regeneration and myelination
Moderate
Improves mild cognitive impairment in older adults
Moderate
Lowers inflammatory markers and cortisol
Limited
May protect against neurodegenerative disease progression
Limited
Stimulates nerve growth factor (NGF) production
Strong
Reduces symptoms of anxiety and depression
Moderate
Source: Examine.com

Expert Evidence

8 references from 3 experts

“Single cell data shows that if you give lion's mane, it seems to encourage nerve growth factor and therefore encourage the regrowth of nerves.”

Why Lions Mane Supplements Are A WASTE Of Money!

0:49

5 references in 1 episode from 2022

2023
2022
Safety & Cautions

Side Effects

  • Mild digestive discomfort
  • Skin rash in sensitive individuals
  • Possible allergic reaction in those with mushroom allergies
Lion's mane is generally well-tolerated with a strong safety profile in clinical studies. Those with mushroom allergies should avoid it, and individuals on anticoagulant or antiplatelet medications should consult a healthcare provider, as it may have mild blood-thinning properties.
Pairs Well With
Omega-3 Fatty Acids (EPA)Alpha-GPCCreatineRhodiola Rosea