Lion's Mane
500-1000mg
With meals
Lion's mane (Hericium erinaceus) is a large, white, shaggy edible mushroom that grows on hardwood trees and has been used in traditional East Asian medicine for centuries. It contains bioactive compounds called hericenones and erinacines that can cross the blood-brain barrier and are studied primarily for their neurological and cognitive benefits.
Research Evidence
Supports nerve regeneration and myelination
ModerateImproves mild cognitive impairment in older adults
ModerateLowers inflammatory markers and cortisol
LimitedMay protect against neurodegenerative disease progression
LimitedStimulates nerve growth factor (NGF) production
StrongReduces symptoms of anxiety and depression
ModerateExpert Evidence
8 references from 3 experts
2023
2022
Safety & Cautions
Side Effects
- Mild digestive discomfort
- Skin rash in sensitive individuals
- Possible allergic reaction in those with mushroom allergies
Lion's mane is generally well-tolerated with a strong safety profile in clinical studies. Those with mushroom allergies should avoid it, and individuals on anticoagulant or antiplatelet medications should consult a healthcare provider, as it may have mild blood-thinning properties.
Pairs Well With