NR (Nicotinamide Riboside)
Nicotinamide riboside (NR) is a form of vitamin B3 that serves as a precursor to nicotinamide adenine dinucleotide (NAD+), a coenzyme essential for cellular energy metabolism. Found in trace amounts in milk and other foods, NR has gained attention for its ability to elevate NAD+ levels, which naturally decline with age. It is one of the most studied NAD+ boosters alongside NMN.
Research Evidence
Potential neuroprotective effects via sirtuin activation
LimitedMay reduce markers of systemic inflammation
ModerateSupports mitochondrial function and cellular energy metabolism
ModerateRaises NAD+ blood levels in humans
StrongMay improve exercise recovery in active individuals
LimitedExpert Evidence
18 references from 3 experts
Safety & Cautions
Side Effects
- Mild nausea
- Flushing at higher doses
- Headache
- Digestive discomfort
NR is generally well-tolerated in clinical trials at doses up to 1,000 mg daily. As with any supplement affecting core metabolic pathways, individuals on medication or with chronic health conditions should consult a healthcare provider before starting.
Pairs Well With