Andrew Huberman on Alpha-GPC

“I take 300 milligrams of alpha GPC now and again before some cognitive work, sometimes before workouts.”

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“Sometimes I'll combine L-Tyrosine with other things like Alpha-GPC.”

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“And indeed, I use these myself. The most effective one I've found is alpha GPC.”

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“Occasionally meaning about once every third sometimes every other but usually about every third workout I'll take 300 milligrams of alpha GPC.”

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“I will often take 300 milligrams of Alpha-GPC prior to workouts or prior to cognitive work bouts.”

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“Alpha-GPC actually will improve your REM sleep. It's one of the few things I've found that can increase energy late in the day and you still sleep better.”

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“The effects on cognitive decline are described as notable. Several studies showed a significant but modest effect on in offsetting cognitive decline, in particular in older populations.”

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“Alpha GPC, which is a form of choline and increases acetylcholine transmission, has been shown to offset some of the effects of age related cognitive decline and improve cognitive functioning.”

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“Alpha-GPC supports the release of a neuromodulator called acetylcholine. 300 milligrams of Alpha-GPC has been shown to increase physical performance but also cognitive performance.”

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“Alpha GPC can improve growth hormone release and fat oxidation, which in theory can support skill learning.”

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“Typically when people are using Alpha-GPC to study or to enhance learning of any kind, they will take somewhere between 300 and 600 milligrams.”

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“Alpha GPC typically is taken in dosages of about 300 to 600 milligrams. For the cognitive effects, the dosages are much higher up to 1200 milligrams daily divided into three doses of 400 milligrams.”

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“If your specific purpose is to enhance learning and memory, you want to spike adrenaline afterwards. You can do that with Alpha GPC.”

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“If you're using those compounds [like Alpha GPC] in order to enhance learning and memory by taking them before or during a learning episode, I encourage you to try and take them either late in the learning episode or immediately after the learning episode.”

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“I would reserve taking the Alpha-GPC to just maybe once or twice a week, maybe three times maximum.”

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“I don't like to do that too often because of the increase in TMAO that occurs, and then you have to take 600 milligrams of garlic to offset that increase.”

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“You're not going to be able to take Alpha GPC and a double espresso, do your focus bout of work, and then spike adrenaline again afterwards and remember that stuff you did even better. I'm discouraging you from chronically increasing adrenaline both during and after a given bout of work.”

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“There have been a few studies that emphasize that people who take a lot of Alpha-GPC chronically over time may be at increased risk for stroke.”

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“Increasing the amount of choline in your system can... increase the amount of TMAO... it does carry some cardiovascular risk.”

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“I'm discouraging you from chronically increasing adrenaline both during and after a given bout of work if the goal is to learn. You're not going to be able to take a Alpha-GPC and a double espresso, do your focus bout of work, and then spike adrenaline again afterwards.”

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