Apigenin

Apigenin is a naturally occurring flavonoid concentrated in chamomile tea, parsley, celery, and other plant foods. It has gained attention primarily as a sleep-supporting compound due to its calming effects on the nervous system. It is one of the most well-studied dietary flavonoids for its sedative and anxiolytic properties.

Andrew HubermanReported use

Research Evidence

May have neuroprotective properties

Limited

Enhances GABAergic neurotransmission

Moderate

Reduces mild anxiety and promotes relaxation

Moderate

Anti-inflammatory effects in preclinical models

Limited

Supports faster sleep onset

Moderate

Source: Examine.com

Expert Evidence

22 references from 2 experts

“I take 50 milligrams of apigenin in capsule form every night before I go to sleep. I've been doing that for well over eight years now.”

How to Control Your Cortisol & Overcome Burnout

1:48:48

20 references in 14 episodes from 2021–2025

Safety & Cautions

Side Effects

Mild sedation or grogginess if taken during the day
Possible digestive discomfort at high doses
Rare allergic reactions in those sensitive to chamomile or related plants

Apigenin is generally well-tolerated at standard supplement doses and is considered safe for nightly use. Those with allergies to plants in the Asteraceae family (chamomile, ragweed) should exercise caution, and pregnant or nursing individuals should consult a healthcare provider before use.

Pairs Well With

GABA

Price Comparison

From $0.12/ct

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Double Wood

4.4

•120 ct

$0.21/ct

$24.95 total

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