GABA

GABA (gamma-aminobutyric acid) is the brain's main inhibitory neurotransmitter, responsible for calming neural activity throughout the central nervous system. It is produced naturally in the body from glutamate and is also available as a dietary supplement derived from fermentation processes. GABA supplements are primarily used to support relaxation, reduce stress, and improve sleep quality.

Andrew HubermanReported use

Research Evidence

Promotes relaxation and reduces subjective stress

Moderate

Improves sleep quality and reduces time to fall asleep

Moderate

May increase growth hormone levels at high doses

Limited

Supports mood and emotional well-being

Limited

Reduces anxiety symptoms in acute stress situations

Moderate

Source: Examine.com

Expert Evidence

2 references from 1 expert

“Every third or fourth night, I will take two grams of glycine and 100 milligrams of GABA in addition to the standard sleep stack... which I find greatly enhances my ability to get into sleep.”

Sleep Toolkit: Tools for Optimizing Sleep & Sleep-Wake Timing

1:17:57

2 references in 2 episodes from 2022–2024

2024

2022

Safety & Cautions

Side Effects

Tingling or flushing sensation
Mild drowsiness
Temporary shortness of breath at high doses
Digestive discomfort

GABA is generally well-tolerated at standard supplemental doses. However, individuals taking medications that affect GABA pathways (such as benzodiazepines, barbiturates, or other sedatives) should consult a healthcare provider before supplementing, as additive effects may occur.

Pairs Well With

Magnesium L-Theanine Ashwagandha Melatonin

Price Comparison

From $0.07/ct

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•100 ct

$0.08/ct

$8.23 total

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