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Nattokinase

Morning

Nattokinase is a serine protease enzyme derived from natto, a traditional Japanese food made by fermenting soybeans with Bacillus subtilis. It has been extensively studied for its fibrinolytic (clot-dissolving) properties and is one of the few dietary enzymes shown to survive digestion and exert systemic effects on blood clot metabolism.

Research Evidence
Breaks down fibrin and supports healthy blood clot dissolution
Strong
May help maintain healthy blood pressure levels
Moderate
Potential anti-atherosclerotic effects on arterial plaque
Limited
Supports healthy circulation and blood flow
Moderate
May reduce blood viscosity and improve rheological properties
Moderate
Source: Examine.com

Expert Evidence

7 references from 2 experts

“We see a reduction of blood pressure of roughly five points, 5 millimeters mercury of systolic blood pressure, from the effect of Nattokinase.”

The #1 Heart Supplement the Internet Got WRONG

2:52

5 references in 1 episode

2023
Safety & Cautions

Side Effects

  • Potential for increased bleeding or bruising
  • Mild gastrointestinal discomfort
  • Possible drop in blood pressure in sensitive individuals
Nattokinase is generally well-tolerated at standard doses. However, it should not be combined with anticoagulant or antiplatelet medications (such as warfarin or aspirin) without medical supervision, and it should be discontinued before scheduled surgeries due to its blood-thinning effects.
Pairs Well With
Omega-3 Fatty Acids (EPA)CoQ10Garlic ExtractVitamin K2