Andrew Huberman on L-Tyrosine
26 episodes · 46 references · 2021–2025
- Huberman views L-tyrosine as a dopamine precursor that can enhance focus, but warns dosing is tricky and excessive intake impairs learning - Discusses L-tyrosine's role in both cognitive function (dopamine pathway) and thyroid hormone production (T3/T4 synthesis with iodine) - No evidence of personal consumption; no specific dosing or timing guidance provided
Benefits
- L-tyrosine acts as a precursor to dopamine and can improve focus and attention - In the thyroid, L-tyrosine combines with iodine to produce T3 and T4 thyroid hormones - Grouped with acetylcholine-boosting compounds as tools that can increase focus
Cautions
- Dosing is very tricky to dial in — can cause excessive euphoria, jitteriness, or over-alertness that paradoxically impairs focus - Taking ~1500mg of L-tyrosine to elevate basal dopamine would be counterproductive, as the resulting dopamine increase would actually be much lower - Chronically elevated baseline dopamine from L-tyrosine supplementation impairs learning capacity
“I'll occasionally take an Alpha-GPC or an L-Tyrosine as well.”
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“I'll take it in dosages of anywhere from 500 milligrams to 1,000 milligrams. I would say I probably take it about once a week maximum for work bouts or workouts.”
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“Full disclosure, I sometimes take L-tyrosine. I'm not taking it right now, but I take it only occasionally.”
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“I do use L-tyrosine from time to time for enhancing Focus motivation.”
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“Maybe every third or fourth workout I'll take 500 milligrams of l-tyrosine.”
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“We've talked about some supplements on the podcast that can replenish dopamine, L-tyrosine in particular.”
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“There are of course supplement-based medications that will increase dopamine mainly L-tyrosine. It is the precursor to dopamine, so it will raise your dopamine levels.”
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“Some people leverage this by taking things like L-tyrosine to increase dopamine.”
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“There are things that can increase focus, mainly things that increase acetylcholine... things that can increase dopamine, things like L-tyrosine.”
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“When we need to attend to multiple things at the same time l-tyrosine can help us do that at least as it relates to memory.”
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“I think the logical, the safe thing to do would be to start with the minimal effective dose. Maybe you start with 250 milligrams of L-tyrosine.”
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“L-Tyrosine is typically taken in dosages of 500 to 1,000 milligrams.”
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“L-tyrosine is typically taken in capsule form or powder form anywhere from 500 to 750 to 1,000 milligrams.”
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“L-tyrosine taken anywhere from 500 to 750 milligrams can increase dopamine because tyrosine is a dopamine precursor.”
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“There is a growing number of people out there that are relying on daily supplementation with anywhere from 1 to 3 grams of L-tyrosine, an amino acid precursor to dopamine.”
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“You'll hear that people will take L-tyrosine, which is the amino acid precursor to dopamine, as a way to try and buffer or increase dopamine during the so-called period of the crash. There's really no evidence that any of those things can be beneficial.”
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“If I were to just elevate my basal level of dopamine by taking, I don't know, 1500 milligrams of L-tyrosine or something, that would be bad because the increase in dopamine would actually be much lower... you're actually going to learn less well.”
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