Andrew Huberman

Andrew Huberman on Berberine

Reported use

16 episodes · 32 references · 2021–2025

Based on dated public statements, not confirmation of use today.

Andrew Huberman has reported taking Berberine. Referenced across 16 episodes with 32 total references.

View full Berberine page with research, safety, and pricing →
Consumption Evidence (4)
Reported useBerberine2:37:54

“I've taken berberine before and I've had two different very distinct experiences with them.”

Intermittent Fasting to Improve Health, Cognition & Longevity | Dr. Satchin Panda

Reported useBerberine24:39

“I've tried berberine before. If you take berberine and you have not ingested carbohydrates, many people, including myself, experience a splitting headache.”

Effects of Fasting & Time Restricted Eating on Fat Loss & Health | Huberman Lab Essentials

Reported useBerberine1:17:49

“I took berberine during the period of maybe somewhere in the 2012 to 2015 stretch. I was and I still am a big fan of Tim Ferriss's slow carbohydrate diet.”

Journal Club with Dr. Peter Attia | Metformin for Longevity & The Power of Belief Effects

Reported useBerberine25:30

“I've actually tried Berberine before; it gave me brutal headaches and I felt really dizzy because it made me hypoglycemic and drove my blood glucose down too far.”

Control Sugar Cravings & Metabolism with Science-Based Tools | Huberman Lab Essentials

Benefits (15)

“Berberine is kind of the poor man's metformin. It's a tree bark extract that also dramatically lowers blood glucose.”

Intermittent Fasting to Improve Health, Cognition & Longevity | Dr. Satchin Panda

“Berberine, which comes from a plant, or metformin are compounds that are now in growing use for reducing blood glucose. They are very potent at reducing blood glucose which will reduce insulin.”

How to Lose Fat with Science-Based Tools

“Berberine is very potent at reducing blood glucose which will reduce insulin. Fat oxidation, this conversion of fatty acids into ATP in the mitochondria, is inhibited by insulin.”

Lose Fat With Science-Based Tools | Huberman Lab Essentials

“Berberine, which is an over the counter substance will lead to very dramatic reductions in blood glucose. And so they shift you from a fed to a fasted state.”

Effects of Fasting & Time Restricted Eating on Fat Loss & Health | Huberman Lab Podcast #41

“Berberine's actions very much mimic Metformin. It activates a certain pathway that's associated with fasting and low blood glucose.”

How Our Hormones Control Our Hunger, Eating & Satiety

Best practices (1)
Best practiceBerberine25:50

“If I took Berberine along with a very large meal that included a lot of carbohydrates, then I felt perfectly fine on even up to 750 milligrams or a gram of Berberine.”

Control Sugar Cravings & Metabolism with Science-Based Tools | Huberman Lab Essentials

Cautions (8)

“Berberine and metformin dramatically reduce blood sugar levels, and if you don't take them with carbohydrates, it can lead to some feelings of discomfort.”

The Science of Healthy Hair, Hair Loss and How to Regrow Hair

“When I took berberine and did not ingest large amounts of simple sugars or carbohydrates along with it, I experienced profound hypoglycemia. I felt like complete garbage for about eight hours and I had one of the worst headaches of my life.”

Intermittent Fasting to Improve Health, Cognition & Longevity | Dr. Satchin Panda

“If you take berberine and you have not ingested carbohydrates, many people, including myself, experience a splitting headache. You become hypoglycemic because it is a glucose clearing agent.”

Effects of Fasting & Time Restricted Eating on Fat Loss & Health | Huberman Lab Podcast #41

“So many guys taking metformin or berberine thinking this is great, I'm going to lower my blood sugar, but also their testosterone levels are getting crushed.”

Female Hormone Health, Fertility & Vitality | Dr. Natalie Crawford

“Berberine gives me brutal headaches. Berberine lowers blood glucose. That's why I think it's giving me brutal headaches.”

AMA #12: Thoughts on Longevity Supplements (Resveratrol, NR, NMN, Etc.) & How to Improve Memory

Stopped Taking (2)

“I'm going to skip the berberine because it gives me brutal headaches and makes me crave carbohydrates because it drops my blood sugar.”

Essentials: Tools for Hormone Optimization in Males | Dr. Kyle Gillett

“When I took berberine, I got a pretty splitting headache. So for me it was a no, almost immediately.”

How Our Hormones Control Our Hunger, Eating & Satiety

Recommends against (2)

“I'm going to skip the berberine because berberine gives me brutal headaches and it makes me crave carbohydrates because it drops my blood sugar.”

Tools for Hormone Optimization in Males | Dr. Kyle Gillett

“I also don't take what some people call the poor man's version of metformin, which is berberine.”

AMA #12: Thoughts on Longevity Supplements (Resveratrol, NR, NMN, Etc.) & How to Improve Memory

Price Comparison
From $0.31/ct
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4.5
•60 ct

$0.31/ct

$18.89 total