Rhonda Patrick

    Rhonda Patrick on Leucine

    With each protein-containing meal

    3 episodes · 3 references · 2018–2024

    AI-generated summary

    - Patrick highlights leucine as the primary anabolic driver in protein, activating mTOR to stimulate muscle protein synthesis - Patrick notes supplemental leucine may partially substitute for high protein intake, citing studies showing modest improvements in muscle protein synthesis response - Patrick cautions that leucine and other branched-chain amino acids compete with tryptophan for brain transport, potentially reducing serotonin precursor availability

    View full Leucine page with research, safety, and pricing →
    Why They Take It (2)

    “Can I supplement with leucine and not have to take in so much protein and have a similar effect on muscle protein synthesis? Guest: We have done some studies where we supplemented people with leucine and we did find that it improved the response a little.”

    Stuart Phillips, PhD, on Building Muscle with Resistance Exercise and Reassessing Protein Intake

    “The main anabolic component of protein is the branched-chain amino acid leucine, which is a potent stimulator of muscle protein synthesis by activating the mTOR pathway.”

    The Science of Protein and Its Role in Longevity, Cancer, Aging, and Building Muscle