
Rhonda Patrick on Leucine
3 episodes · 3 references · 2018–2024
- Patrick highlights leucine as the primary anabolic driver in protein, activating mTOR to stimulate muscle protein synthesis - Patrick notes supplemental leucine may partially substitute for high protein intake, citing studies showing modest improvements in muscle protein synthesis response - Patrick cautions that leucine and other branched-chain amino acids compete with tryptophan for brain transport, potentially reducing serotonin precursor availability
View full Leucine page with research, safety, and pricing →“Can I supplement with leucine and not have to take in so much protein and have a similar effect on muscle protein synthesis? Guest: We have done some studies where we supplemented people with leucine and we did find that it improved the response a little.”
Stuart Phillips, PhD, on Building Muscle with Resistance Exercise and Reassessing Protein Intake




