Rhonda Patrick on Melatonin

“I take three milligrams of melatonin in the evening.”

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“Melatonin has been shown to bind to receptors on the pancreas and this signals to the pancreas to stop producing insulin.”

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“They're having too much bright blue light exposure inhibiting their melatonin at night so they're not they're sort of becoming these night owls.”

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“There have been studies done with supplemental melatonin in breast cancer patients where they've given them really high doses. In conjunction with other traditional therapies like radiation, it increases the one-year survival rate from 36% to about 65%.”

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“Melatonin's a hormone that regulates 500 different genes. That's two and a half percent of the human genome.”

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“Melatonin regulates the expression of 500 different genes. It increases the expression of antioxidant genes in the cortex and has been shown to regulate REM sleep.”

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“Our bodies naturally produce melatonin about three or so hours before our natural bedtime. It's a good rule of thumb to make sure that you have finished your last meal before that time.”

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“A certain variation in the melatonin receptor 1B was identified to be a pretty high risk factor for developing type 2 diabetes. People with that gene variation had a hypersensitive receptor where little bits of melatonin were enough to really activate it.”

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“Melatonin actually can inhibit the secretion of insulin from the beta cells in the pancreas, and that would obviously affect your blood glucose levels.”

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“One thing I would not advise is to mix melatonin with alcohol in an attempt to fall asleep or improve your sleep. This will lead to increased drowsiness and may not be safe.”

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