Brad Stanfield on TMG (Trimethylglycine)
27 episodes · 37 references · 2022–2025
- Stanfield actively takes TMG daily and includes it in his Micro Vitamin product for exercise performance and homocysteine reduction - Cites good human evidence for improved muscle performance, testosterone levels, and potential dementia risk reduction via homocysteine lowering - Cautions that high doses (2-4g+) can raise LDL and total cholesterol levels
Consumption
- Takes at least 500mg of TMG daily and includes it in his Micro Vitamin supplement - Supplements specifically for both exercise performance and cognitive benefits - Uses TMG (betaine) as part of his recovery stack alongside creatine monohydrate
Benefits
- Studies show TMG enhances strength, power, endurance, and testosterone levels in exercising subjects versus placebo - Lowers homocysteine by donating methyl groups to convert it to methionine, potentially reducing Alzheimer's risk - May boost creatine production, increase nitric oxide, enhance ATP recycling, and support muscle protein synthesis
Best Practices
- Recommends 500mg dose for homocysteine reduction - Works best combined with resistance and power training that poses high metabolic demands - No specific timing guidance discussed beyond daily supplementation
Cautions
- High doses of 2-4g can increase LDL cholesterol levels - Doses of 4g or more can raise total cholesterol - No warnings discussed regarding drug interactions or contraindicated populations
“I take at least 500 milligrams of TMG every day.”
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“I personally take trimethyl glycine daily and I included it in my provitamin.”
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“It's not just for muscle performance reasons for why I take TMG.”
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“This is why I include TMG in micro vitamin to help me boost my exercise performance.”
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“I also wanted to take a supplement that included trimethylglycine or TMG for its proposed cognitive and exercise effects.”
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“A study in soccer players who supplemented with TMG found increases in testosterone levels during a season compared to the placebo group.”
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“I also wanted to package it with TMG for exercise performance.”
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“TMG supplementation can improve both muscle performance and testosterone levels.”
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“TMG may reduce a risk factor for Alzheimer's by lowering homocysteine levels.”
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“Studies have found that it can significantly improve muscle performance and the quality of our workouts.”
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“Trimethylglycine 500 milligrams reduces homocysteine levels. High homocysteine levels are linked with Alzheimer's disease.”
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“It's likely that TMG works best in this type of training environment that poses high metabolic demands. We need to combine it with exercise, specifically resistance and power training.”
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