Brad Stanfield on Hyaluronic Acid
33 episodes · 54 references · 2022–2025
- Stanfield actively takes 200 mg hyaluronic acid daily and considers it one of his core skin-health supplements, citing multiple RCTs showing ~18% wrinkle reduction. - He has thoroughly addressed the cancer concern, concluding that mouse studies show no effect on cancer growth from supplementation. - He recommends against expensive high molecular weight forms and topical serums, favoring low molecular weight oral supplements at 200 mg.
Consumption
- Takes 200 mg hyaluronic acid daily as part of his regular supplement stack. - Initially used expensive high molecular weight form but has since switched based on absorption evidence. - Takes it alongside collagen peptides specifically for skin health benefits.
Benefits
- Cites multiple RCTs showing ~18.8% reduction in wrinkle depth versus 2.6% for placebo. - Highlights hyaluronic acid's unique water-binding capacity for skin hydration, with one trial showing ~10% moisture improvement in 28 days. - Notes improvements in skin elasticity, firmness, and barrier function across double-blind placebo-controlled studies.
Best Practices
- Recommends 200 mg daily, the most commonly used dose in clinical trials. - Advises choosing low molecular weight hyaluronic acid for optimal absorption. - High molecular weight forms don't get absorbed intact and must be broken down, making them a waste of money.
Cautions
- Addresses the social media cancer concern: in-vitro studies showed accelerated cancer cell growth, but mouse studies with existing tumors found no difference. - Some people may experience mild stomach upset from supplementation. - Recommends against topical hyaluronic acid serums for anti-aging, calling them no better than placebo in an industry-sponsored study.
“I take 200 milligrams of high molecular weight hyaluronic acid every day.”
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“I also take collagen peptides and hyaluronic acid for skin health.”
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“When I first started taking hyaluronic acid supplements, it was this kind of evidence that convinced me to go for the more expensive high molecular weight hyaluronic acid.”
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“I personally take a hyaluronic acid supplement.”
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“Personally I take 200 milligrams of hyaluronic acid every day.”
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“Hyaluronic acid supplements improved skin moisture, and a small trial suggested that hyaluronic acid decreased wrinkle depth compared to a placebo.”
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“Collagen peptides also stimulate the production of hyaluronic acid. This acid has a unique ability to bind and hold on to water; it's the key molecule when it comes to moisture.”
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“Then we've got hyaluronic acid and collagen peptides for skin health.”
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“After only 28 days of supplementing with hyaluronic acid compared to placebo, there were significant improvements in skin health. The skin was more hydrated by about 10% and wrinkles decreased by almost 20%.”
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“We've got fantastic evidence from randomized control trials showing that if we supplement with hyaluronic acid we reduce skin wrinkles by about 18%.”
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“To optimize absorption we should be going for a low molecular weight hyaluronic acid supplement.”
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“The 200 mg dose is the most commonly used dose in the existing clinical trials.”
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“I also take hyaluronic acid 200 mg as part of my micro-vitamin.”
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“Hyaluronic acid skin serums they're no better than placebo and crucially this was also industry sponsored.”
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“There's no reason to buy expensive high molecular weight hyaluronic acid. It doesn't get absorbed in that form and it has to be broken down.”
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