Brad Stanfield on NR (Nicotinamide Riboside)
6 episodes · 7 references · 2021–2025
- Stanfield does not supplement with NR and does not recommend it to patients, finding the evidence unconvincing. - Raises concerns about mixed trial results, lack of lifespan extension, and all B3 forms increasing 4PY levels. - No evidence of personal consumption or specific dosing guidance for individual use.
Benefits
- NR helps support NAD levels, which decline with aging. - Mentioned as an ingredient in a multi-supplement combination protocol at 1g dose. - Stanfield acknowledges the NAD-boosting mechanism but does not find it sufficient to justify supplementation.
Best Practices
- Referenced a combination protocol using 1 gram of nicotinamide riboside. - The dose was part of a multi-supplement intervention, not a standalone recommendation. - No specific timing, cycling, or form preferences discussed beyond the 1g dose point.
Cautions
- The ITP (Interventions Testing Program) found no lifespan extension and no other benefits from NR, with mixed overall results. - All forms of vitamin B3, including NR, increase 4PY levels, which is a potential health concern. - Stanfield explicitly states he does not supplement with NR and would not recommend it to patients.
“There's a lot of trials going on combining exercise with NAD precursor molecules such as NR because we're hoping that when these molecules are combined with exercise, they will give further strength benefits.”
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“The next ingredient is nicotinamide riboside which helps to support NAD levels.”
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“The combination of supplements included one gram of nicotinamide riboside.”
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“I don't find it particularly convincing and I'm not about to start recommending nicotinamide riboside supplements to my patients. I personally don't supplement with it.”
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