Rhonda Patrick on NR (Nicotinamide Riboside)
2 episodes · 6 references · 2019–2020
- Patrick highlights NR's potential to boost NAD levels by 60% at 1g/day and reverse mitochondrial damage in animal models - She notes possible cancer risk in specific contexts where pro-inflammatory senescent cells drive tumor growth - No evidence of personal consumption; her discussion is research-focused rather than endorsement-based
Benefits
- High-dose NR reversed mitochondrial damage, increased mitochondrial biogenesis, and reversed muscular atrophy in animal disease models - 500mg twice daily (1g/day) for six weeks was well tolerated and raised NAD levels in white blood cells by 60% - Oral high-dose NR counteracted obesogenic diet effects, improving insulin sensitivity, endurance, and strength in animal studies
Best Practices
- Patrick recommends ensuring NR products are kept cool and not stored in hot warehouses - She advises purchasing directly from manufacturers to guarantee product integrity - Temperature sensitivity of NR means supply chain handling matters for efficacy
Cautions
- NR may promote tumor growth in cancers driven by pro-inflammatory senescent cells - This risk is context-specific rather than a blanket warning against supplementation - Patrick frames this as a possibility warranting awareness, not a definitive contraindication
“At high dose, nicotinamide riboside could reverse mitochondrial damage, it could increase mitochondrial biogenesis, and reverse muscular atrophy in animals that had a severe muscle wasting disease.”
NAD+ in Aging: Role of Nicotinamide Riboside and Nicotinamide Mononucleotide
“A 500 milligram dose of nicotinamide riboside twice daily for a total of one gram per day for six weeks was well tolerated and increased NAD levels in white blood cells by 60%.”
NAD+ in Aging: Role of Nicotinamide Riboside and Nicotinamide Mononucleotide
“When nicotinamide riboside is orally administered at high doses, it can counteract an obesogenic diet by improving insulin sensitivity, and it can improve endurance and strength.”
NAD+ in Aging: Role of Nicotinamide Riboside and Nicotinamide Mononucleotide
“It's a good idea to make sure that these products stay cool as much as possible and get them from a manufacturer to make sure that they have not been laying around in a hot warehouse somewhere longer than necessary.”
NAD+ in Aging: Role of Nicotinamide Riboside and Nicotinamide Mononucleotide
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