Rhonda Patrick on Sulforaphane (Glucoraphanin)
14 episodes · 45 references · 2013–2025
- Patrick is a strong advocate for sulforaphane, consuming 40-60mg daily through sprouting broccoli sprouts and citing extensive cancer, cardiovascular, and detoxification research. - Cites specific clinical data: 86% slowing of PSA doubling in prostate cancer, 61% increased benzene excretion, 22% reduced all-cause mortality in top cruciferous vegetable consumers. - No dosing best-practice guidance, caution warnings, or recommendations against use were discussed.
Consumption
- Patrick consumes 40-60mg of sulforaphane daily through home-sprouted broccoli sprouts. - Sprouting is her preferred delivery method for sustained daily intake. - No specific brand, timing protocol, or cycling schedule mentioned.
Benefits
- Cancer protection: 44% lower bladder cancer, 40% lower prostate cancer, 55% lower lung cancer risk in cruciferous vegetable consumers; 86% slower PSA doubling at 60mg/day in prostate cancer patients. - Detoxification: 61% increased benzene excretion and 50% increased excretion of acrolein and other carcinogens via broccoli sprout beverages. - Metabolic and cardiovascular: 20% drop in fasting blood sugar in type 2 diabetics, 18.7% lower triglycerides, 22% reduced all-cause mortality in highest cruciferous vegetable consumers.
“I've really gotten back on the sulforaphane train and I take sulforaphane.”
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“Once the water is hot enough, I pour it on the sprouts and wait 10 minutes. I either rinse them off to cool them for a salad, or I put them into the blender with just enough ice and water to make a cup I can drink down.”
How To Increase Sulforaphane in Broccoli Sprouts by ~3.5-fold
“I'm able to sustain my 40 to 60 milligram of sulforaphane a day by sprouting.”
Sulforaphane and Its Effects on Cancer, Mortality, Aging, Brain and Behavior, Heart Disease & More
“I'm taking avmacol so I'm taking that's my sulfurane that I take I take two of those.”
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“Men with low-grade prostate cancer that were supplementing with about 60 milligrams of sulforaphane a day slowed the doubling of their PSA antigen by about 86%.”
Dr. Rhonda Patrick: Optimizing Longevity with Micronutrients & Vigorous Exercise
“There's a compound found in some cruciferous vegetables and in particularly in broccoli sprouts, the young sprout of mature broccoli, called sulforaphane, which has been shown in now quite a few studies to increase the excretion of benzene.”
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“Breast tissue displayed increased levels of a gene called NQO1, which makes an enzyme that protects a very important tumor suppressor gene called P53 from being degraded.”
Sulforaphane and Its Effects on Cancer, Mortality, Aging, Brain and Behavior, Heart Disease & More
“After receiving broccoli sprout extract containing about 37 milligrams of sulforaphane, the accumulation of sulforaphane was detected in actual human breast tissue.”
Sulforaphane and Its Effects on Cancer, Mortality, Aging, Brain and Behavior, Heart Disease & More
“Men who ate two or more half cup servings of broccoli per week had a 44% lower incidence of bladder cancer.”
Sulforaphane and Its Effects on Cancer, Mortality, Aging, Brain and Behavior, Heart Disease & More
“If you add mustard seed powder to your broccoli, it can increase that bioavailability. It basically helps by adding an exogenous source of that enzyme back to the broccoli.”
Dr. Rhonda Patrick: Optimizing Longevity with Micronutrients & Vigorous Exercise
“The best protocol for your sprouts is about 10 minutes at 70 degrees Celsius, or 60 degrees Celsius if you're doing this to mature broccoli florets.”
How To Increase Sulforaphane in Broccoli Sprouts by ~3.5-fold
“Broccoli sprouts are a great source of sulforaphane. About 45 to 100 grams a day gets you about some of the doses that I talked about in these studies.”
Dr. Rhonda Patrick: Optimizing Longevity with Micronutrients & Vigorous Exercise
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