Brad Stanfield on N-Acetyl Cysteine (NAC)
6 episodes · 9 references · 2021–2024
- Stanfield advocates NAC as a glutathione precursor to improve resilience to disease and mitochondrial function, especially in older adults - Recommends 1.5g twice daily as an ideal dose, with plans to start personally at age 50 - No evidence of current personal consumption; one caution noted regarding blood thinning
Benefits
- NAC rebuilds glutathione stores, making the body more resilient to disease - Glycine and NAC supplementation in older adults corrected glutathione deficiency and improved mitochondrial function - Supports glutathione levels by providing its building blocks (NAC and glycine)
Best Practices
- Ideal NAC dose is around 1.5g twice daily based on available evidence - Clinical study used 100mg/kg dosing (8g for an 80kg person), which Stanfield notes is quite high - Stanfield plans to take 1.5g NAC with serine twice daily starting at age 50
Cautions
- NAC can thin the blood, posing risks for people with bleeding disorders - Those on blood-thinning medications should avoid NAC - No other safety concerns or contraindications discussed
“By supplementing with the building blocks of glutathione, so NAC and glycine, we can help support our glutathione levels.”
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“If we take a supplement called N-acetylcysteine or NAC, we can rebuild our glutathione stores and make our bodies more resilient to disease.”
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“Glycine and NAC supplements in older adults significantly corrected the glutathione deficiency and improved their mitochondrial function.”
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“Overall from this human study, we can see that glycine and NAC supplements in older adults significantly improved and corrected the glutathione deficiency.”
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“The combination of supplements included two and a half grams of neck.”
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“I plan to take one and a half grams of NAC and serine twice a day when I reach the age of 50 years old.”
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“An argument can be made that the ideal dose of NAC would be around 1.5 grams twice a day.”
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“Glycine and NAC were each dosed at 100 milligrams per kilogram, which is quite a high dose. For an 80 kilogram person, they are taking 8 grams of both glycine and NAC.”
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